Abstract: The hypothesis of polygenic/multifactorial causes for MRKH syndrome（congenital utero-vaginal aplasia） has been reinforced，as well as familial heredity and aggregation. Vaginoplasty is the main treatment method. With the application and improvement of laparoscopic operation and tissue engineering technique，researchers have been trying to continuously develop and innovate vaginoplasty，then evaluate the effectiveness of different procedure by long-term follow-up. The article below will overview the causes，the main methods of operation of MRKH and their follow-up results.

Key words: Vagina, Laparoscopes, Tissue engineering, Follow-up studies, Therapy, MRKH syndrome