The Research Progress of Vascular Endothelial Growth Factor and Cervical Cancer Metastasis

Journal of International Obstetrics and Gynecology ›› 2011, Vol. 38 ›› Issue (3): 241-244.

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The Research Progress of Vascular Endothelial Growth Factor and Cervical Cancer Metastasis

PENG Xiao-lian，WU Yi-lin

Department of Obstetrics and Gynecology，the people′s Hospital of Linxiang City, Hunan Province，Linxiang 414300，China（PENG Xiao-lian）；The Second Xiangya Hospital of Central South University，Changsha 410011，China（WU Yi-lin）

Received:1900-01-01 Revised:1900-01-01 Published:2011-06-15 Online:2011-06-15

Abstract

Abstract: Vascular endothelial growth facto（VEGF） is a potent mitogen of angiogenesis.It can induce angiogenesis and lymphangiogenesis in tumor.Furthermore，VEGF significantly associates with lymphatic metastasis and prognosis of cervical carcinoma.VEGF causes hyperpermeable formation of vessel，leading to resistance to blood flow and impair blood supply and therefore compromise the distribution and effectiveness of conventional cytotoxic therapies.Aantagonist may induce the morphological normalization of tumor vasculature and increase drug uptake. It is currently a hot topic in molecular targeted therapies of cervical carcinoma.

Key words: Vascular endothelial growth factors, Uterine cervical neoplasms, Neoplasm metastasis, Angioge- nesis inhibitors

PENG Xiao-lian;WU Yi-lin. The Research Progress of Vascular Endothelial Growth Factor and Cervical Cancer Metastasis[J]. Journal of International Obstetrics and Gynecology, 2011, 38(3): 241-244.

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The Research Progress of Vascular Endothelial Growth Factor and Cervical Cancer Metastasis

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