Methods and Research Advances in Prevention of the Recurrence of IUA after Hysteroscopic Adhesiolysis

doi:10.12280/gjfckx.20201136

Abstract

Abstract:

Intrauterine adhesions (IUA) refers to the damage of endometrial basal layer caused by many factors. Patients with IUA may present with menstrual abnormalities, infertility, recurrent miscarriages. Sequelae of pregnancy in the presence of adhesions include higher incidences of premature labor, and abnormal placentation. Hysteroscopic surgery is the standard operation for the treatment of IUA. However, the recurrence rate of adhesions in patients with moderate to severe IUA is high, which seriously affects the reproductive prognosis of patients. At present, the clinical methods to prevent postoperative adhesion recurrence include promoting endometrial growth and repair with estrogen or other drugs, stent placement in the uterine cavity, inhibiting the inflammatory reaction of the wound with hyaluronic acid, amniotic membrane products placement in the uterine cavity, second-look hysteroscopy, treatment of chronic endometritis, etc. There are still some new measures in the research stage, such as intrauterine injection of endometrial growth factor, stem cell therapy and so on. In the clinical practice, there is no unified treatment plan nowadays, and most patients are treated with a combination regimen.

Key words: Tissue adhesions, Uterus, Intrauterine adhesions, Recurrence, Estrogens, Saccule and utricle, Amnion

JIANG Wen-jun, HUANG Xiao-wu. Methods and Research Advances in Prevention of the Recurrence of IUA after Hysteroscopic Adhesiolysis[J]. Journal of International Obstetrics and Gynecology, 2021, 48(4): 409-414.

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