The Role of Macrophages in Neurogenesis and Angiogenesis in Endometriosis and Its Mechanism

doi:10.12280/gjfckx.20210737

Abstract

Abstract:

Endometriosis (EMs) is a common disease in women of childbearing age and its pathogenesis is not yet clear. Neurofibrogenesis and angiogenesis are important mechanisms for disease progression, chronic pelvic pain, and enlargement of endometriosis lesions, and the causes are also very complex, which is likely to be closely related to the change of EMs immune microenvironment. Macrophages, an important component of the immune environment in EMs, are abnormally recruited and produce morphological and functional changes during disease development, secreting various pro- and anti-inflammatory cytokines, causing hyperexcitability of neural signals and abnormal pathway transduction, participating in the regulation of vascular endothelia growth factor (VEGF) pathway and playing an important role in neuroangiogenesis. This paper summarizes the role of macrophages in the formation of nerve fibres and blood vessels in EMs and their potential mechanisms, and provides theoretical support for targeting EMs macrophages to intervene in the inflammatory process and peripheral nerve and blood vessel generation, and provides new ideas for understanding the pathogenesis of EMs.

Key words: Endometriosis, Macrophages, Nerve fibers, Neovascularization,pathologic, Phenotype

MEI Shan-shan, DING Jie, NI Zhe-xin, CHENG Wen, YU Chao-qin. The Role of Macrophages in Neurogenesis and Angiogenesis in Endometriosis and Its Mechanism[J]. Journal of International Obstetrics and Gynecology, 2022, 49(1): 106-110.

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