Application of 3D Bioprinted Endometrial Regenerative Cell Biological Scaffold in Intrauterine Adhesions

doi:10.12280/gjfckx.20210456

Abstract

Abstract:

The existing treatment of intrauterine adhesions has limitations, such as high recurrence rate and low pregnancy rate. There is little help for endometrial regeneration and functional recovery, and there is no optimal treatment strategy for this problem. In recent years, stem cells have become a research focuses in the treatment of intrauterine adhesions, and how to maintain the biological activity of cells in vivo has become a key issue. 3D bio-printing technology can simulate the microenvironment of the transplanted cells in vitro, providing an effective guarantee for the therapeutic effect. At present, endometrial regenerative cells (ERC) with the characteristics of stem cells have been obtained from female menstrual blood, and found to have strong proliferative ability and multidirectional differentiation potential. However, it has not been reported whether ERC bio-scaffolds constructed by 3D bioprinting technology can be transplanted to treat intrauterine adhesions. This review briefly introduced the key technologies, cells and bio-inks of 3D bioprinting, and prospected the feasibility and limitations of the application of 3D bioprinted endometrial regenerative cell bioscaffolds for the treatment of intrauterine adhesions.

Key words: Bioprinting, Printing,three-dimensional, Uterine diseases, Tissue adhesions, Stem cells, 3D bioprinting technology, Endometrial regenerative cells, Intrauterine adhesions, Bio-ink

XIA Rui-qi, KONG Xian-chao. Application of 3D Bioprinted Endometrial Regenerative Cell Biological Scaffold in Intrauterine Adhesions[J]. Journal of International Obstetrics and Gynecology, 2022, 49(1): 111-115.

Figures/Tables 2

References 30

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打印技术	材料黏度（mPa/s）	打印速度	细胞活力	费用	细胞密度
喷墨式生物打印^[9]	3.5~12	快	>85%	低	低,<10⁶个细胞/mL
挤出式生物打印^[8]	30~>6×10⁷	中等	40%~80%	中等	高,细胞球状体
激光辅助生物打印^[10]	1~300	慢	>95%	高	中等,10⁸个细胞/mL

打印技术	材料黏度（mPa/s）	打印速度	细胞活力	费用	细胞密度
喷墨式生物打印^[9]	3.5~12	快	>85%	低	低,<10⁶个细胞/mL
挤出式生物打印^[8]	30~>6×10⁷	中等	40%~80%	中等	高,细胞球状体
激光辅助生物打印^[10]	1~300	慢	>95%	高	中等,10⁸个细胞/mL