Application of Stem Cells in Intrauterine Adhesion Treatment

doi:10.12280/gjfckx.20220289

Abstract

Abstract:

Endometrium is an essential component of the uterus and the site of embryo implantation. Several factors, including infection, abortion, excessive uterine curettage and so on, can lead to the damage of endometrial basal layer and intrauterine adhesion. It may result in several clinical manifestations such as amenorrhea, dysmenorrhea, sub-fertility/infertility and recurrent abortions to affect the physical and mental health and quality of life. However, various treatments for intrauterine adhesion has limited efficacy, which results in a high frequency of recurrence. The wide-ranging applications of stem cells in regenerative medicine is emerging as a potential therapy to treat intrauterine adhesion, which is to repaire and regenerate the endometrium. Number of pre-clincal reports has demonstrated stem cells treatment can decrease the fibrotic area, and increase the number of glands and the endometrial thickness and in animal models. This article reviews the theoretical basis of stem cell therapy for intrauterine adhsions and the research progress of stem cells and their derivatives in the treatment of intrauterine adhesions.

Key words: Uterine diseases, Endometrium, Tissue adhesions, Stem cell transplantation, Mesenchymal stromal cells, Regenerative medicine

ZHANG Shu-rong, YANG Chun-run, SHAO Xu-ping, ZOU Yong-hui, LI Chang-zhong. Application of Stem Cells in Intrauterine Adhesion Treatment[J]. Journal of International Obstetrics and Gynecology, 2022, 49(4): 466-471.

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