The Role of Endometrial and Intestinal Microbiome in the Pathogenesis of Endometrial Carcinoma

doi:10.12280/gjfckx.20211095

Abstract

Abstract:

Endometrioid carcinoma (EC) is one of the three major gynecological malignancies. In recent years, with the development of high-throughput sequencing and high-resolution imaging technology, the correlation between the composition and changes of endometrioid and intestinal microbiota and EC has been increasing gradually. Current studies have shown that changes in endometrial microorganisms under disease or sub-health state can produce pro-inflammatory molecules, such as interleukin and tumor necrosis factor, and affect endometrial cell proliferation. Intestinal dysbiosis may induce endometrial atypical hyperplasia or can ceration by interfering with the metabolism of intestinal microbiota with β-glucuronase and thereby affecting estrogen levels. This article reviews the role of endometrium and intestinal microbiome in the pathogenesis of EC, and discusses whether the intervention based on endometrial and intestinal microflora can provide new research ideas and directions for the treatment and management of patients with EC.

Key words: Microbiota, Endometrial neoplasms, Carcinoma, Endometrium, Gastrointestinal tract, Inflammation, Estrogens

MA Xing, HUANG Wu-nan, LIU Wen-wen, LI Ling, LIU Chang. The Role of Endometrial and Intestinal Microbiome in the Pathogenesis of Endometrial Carcinoma[J]. Journal of International Obstetrics and Gynecology, 2022, 49(4): 366-370.

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