Research Progress of MicroRNAs in Exosomes from Different Sources in Pre-Eclampsia

doi:10.12280/gjfckx.20211014

Abstract

Abstract:

The pathogenesis of pre-eclampsia (PE) remains unclear. However, exosomes provide a new direction for the study of the pathogenesis of PE. Studies have shown that exosomes are widespread in the human body, and cells such as red blood cells, epithelial cells, mesenchyme stem cells, and placental cells can secrete exosomes. The microRNAs (miRNAs) in exosomes from different sources have been shown to play a definite role in the occurrence and prevention of PE. For example, miRNAs in exosomes derived from the placenta may be closely related to the pathogenesis of PE, and miRNAs in cord blood-derived exosomes may have a certain relationship with embryonic development. While miRNAs in mesenchyme stem cell-derived exosomes may play an important role in the treatment of PE. These miRNAs in exosomes from diverse sources are associated with the occurrence and development of PE. Therefore, it is important to investigate the origin of these mirnas and their exosomes in order to understand the pathogenesis and target therapy of PE..

Key words: Pre-eclampsia, Exosomes, MicroRNAs, Placenta, Mesenchymal stromal cells

HE Dou-dou, SUN Xiao-tong, ZHANG Hui-fang, ZHANG Chun-yang. Research Progress of MicroRNAs in Exosomes from Different Sources in Pre-Eclampsia[J]. Journal of International Obstetrics and Gynecology, 2022, 49(4): 426-429.

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