Epithelial-Mesenchymal Transition and Decidualization in Endometrial Receptivity

doi:10.12280/gjfckx.20210881

Abstract

Abstract:

Implantation of the embryo is a key step in the process of conception which involves complex factors. Successful implantation entails a viable embryo to be implanted into an acceptable endometrium at an appropriate time, and a state of synchronous communication between the embryo and the endometrium. Errors in any part of the implantation process will affect the pregnancy rate, wherein decreased endometrial receptivity may be implicated as one of the major causes of infertility. During the early stage of implantation, endometrial epithelial cells undergo epithelial-mesenchymal transition to facilitate embryo adhesion, followed by decidualization of endometrial stromal cells to provide a suitable environment for embryo development. This suggests that epithelial-mesenchymal transition and decidualization is the fundamental condition for maintaining the receptive state of the endometrium, and an acceptable endometrium is the biological basis for embryo implantation and full development.

Key words: Epithelial-mesenchymal transition, Decidua, Endometrium, Embryo implantation, Infertility,female

JIN Jie, XIONG Wen-qian, LIU Yi. Epithelial-Mesenchymal Transition and Decidualization in Endometrial Receptivity[J]. Journal of International Obstetrics and Gynecology, 2022, 49(3): 325-339.

References 30

[1]	Adiguzel D, Celik-Ozenci C. FoxO1 is a cell-specific core transcription factor for endometrial remodeling and homeostasis during menstrual cycle and early pregnancy[J]. Hum Reprod Update, 2021, 27(3):570-583. doi: 10.1093/humupd/dmaa060. doi: 10.1093/humupd/dmaa060 pmid: 33434267
[2]	Liang J, Cao D, Zhang X, et al. miR-192-5p suppresses uterine receptivity formation through impeding epithelial transformation during embryo implantation[J]. Theriogenology, 2020, 157:360-371. doi: 10.1016/j.theriogenology.2020.08.009. doi: 10.1016/j.theriogenology.2020.08.009
[3]	Fullerton PT Jr, Monsivais D, Kommagani R, et al. Follistatin is critical for mouse uterine receptivity and decidualization[J]. Proc Natl Acad Sci U S A, 2017, 114(24):E4772-E4781. doi: 10.1073/pnas.1620903114. doi: 10.1073/pnas.1620903114
[4]	Kasvandik S, Saarma M, Kaart T, et al. Uterine Fluid Proteins for Minimally Invasive Assessment of Endometrial Receptivity[J]. J Clin Endocrinol Metab, 2020, 105(1):dgz019. doi: 10.1210/clinem/dgz019. doi: 10.1210/clinem/dgz019
[5]	Tan Q, Shi S, Liang J, et al. Endometrial cell-derived small extracellular vesicle miR-100-5p promotes functions of trophoblast during embryo implantation[J]. Mol Ther Nucleic Acids, 2021, 23:217-231. doi: 10.1016/j.omtn.2020.10.043. doi: 10.1016/j.omtn.2020.10.043
[6]	Stepanjuk A, Koel M, Pook M, et al. MUC20 expression marks the receptive phase of the human endometrium[J]. Reprod Biomed Online, 2019, 39(5):725-736. doi: 10.1016/j.rbmo.2019.05.004. doi: S1472-6483(19)30538-3 pmid: 31519421
[7]	Gou J, Hu T, Li L, et al. Role of epithelial-mesenchymal transition regulated by twist basic helix-loop-helix transcription factor 2 (Twist2) in embryo implantation in mice[J]. Reprod Fertil Dev, 2019, 31(5):932-940. doi: 10.1071/RD18314. doi: 10.1071/RD18314
[8]	汪沙, 段华, 郑德璇. 上皮-间质转化在子宫腺肌病中作用的研究进展[J]. 国际妇产科学杂志, 2020, 47(1):92-96. doi: 10.3969/j.issn.1674-1870.2020.01.022. doi: 10.3969/j.issn.1674-1870.2020.01.022
[9]	Owusu-Akyaw A, Krishnamoorthy K, Goldsmith LT, et al. The role of mesenchymal-epithelial transition in endometrial function[J]. Hum Reprod Update, 2019, 25(1):114-133. doi: 10.1093/humupd/dmy035. doi: 10.1093/humupd/dmy035 pmid: 30407544
[10]	Cui D, Sui L, Han X, et al. Aquaporin-3 mediates ovarian steroid hormone-induced motility of endometrial epithelial cells[J]. Hum Reprod, 2018, 33(11):2060-2073. doi: 10.1093/humrep/dey290. doi: 10.1093/humrep/dey290
[11]	Lin X, Chai G, Wu Y, et al.RNA m(6)A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail[J]. Nat Commun, 2019, 10(1):2065. doi: 10.1038/s41467-019-09865-9. doi: 10.1038/s41467-019-09865-9
[12]	Ran J, Yang HH, Huang HP, et al. ZEB1 modulates endometrial receptivity through epithelial-mesenchymal transition in endometrial epithelial cells in vitro[J]. Biochem Biophys Res Commun, 2020, 525(3):699-705. doi: 10.1016/j.bbrc.2020.02.153. doi: 10.1016/j.bbrc.2020.02.153
[13]	Li Z, Gou J, Jia J, et al. MicroRNA-429 functions as a regulator of epithelial-mesenchymal transition by targeting Pcdh8 during murine embryo implantation[J]. Hum Reprod, 2015, 30(3):507-518. doi: 10.1093/humrep/dev001. doi: 10.1093/humrep/dev001
[14]	Liu W, Niu Z, Li Q, et al. MicroRNA and Embryo Implantation[J]. Am J Reprod Immunol, 2016, 75(3):263-271. doi: 10.1111/aji.12470. doi: 10.1111/aji.12470
[15]	Li L, Gou J, Yi T, et al. MicroRNA-30a-3p regulates epithelial-mesenchymal transition to affect embryo implantation by targeting Snai2[J]. Biol Reprod, 2019, 100(5):1171-1179. doi: 10.1093/biolre/ioz022. doi: 10.1093/biolre/ioz022
[16]	Akbar R, Ullah K, Rahman TU, et al. miR-183-5p regulates uterine receptivity and enhances embryo implantation[J]. J Mol Endocrinol, 2020, 64(1):43-52. doi: 10.1530/JME-19-0184. doi: 10.1530/JME-19-0184
[17]	Ghahhari NM, Babashah S. Interplay between microRNAs and WNT/β-catenin signalling pathway regulates epithelial-mesenchymal transition in cancer[J]. Eur J Cancer, 2015, 51(12):1638-1649. doi: 10.1016/j.ejca.2015.04.021. doi: 10.1016/j.ejca.2015.04.021
[18]	Shariati M, Niknafs B, Seghinsara AM, et al. Administration of dexamethasone disrupts endometrial receptivity by alteration of expression of miRNA 223, 200a, LIF, Muc1, SGK1, and ENaC via the ERK1/2-mTOR pathway[J]. J Cell Physiol, 2019, 234(11):19629-19639. doi: 10.1002/jcp.28562. doi: 10.1002/jcp.28562
[19]	Shokrzadeh N, Alivand MR, Abedelahi A, et al. Calcitonin administration improves endometrial receptivity via regulation of LIF, Muc-1 and microRNA Let-7a in mice[J]. J Cell Physiol, 2019, 234(8):12989-13000. doi: 10.1002/jcp.27969. doi: 10.1002/jcp.27969 pmid: 30536902
[20]	Salker M, Teklenburg G, Molokhia M, et al. Natural selection of human embryos: impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss[J]. PLoS One, 2010, 5(4):e10287. doi: 10.1371/journal.pone.0010287. doi: 10.1371/journal.pone.0010287
[21]	Xu Y, Lu J, Wu J, et al. HOXA10 co-factor MEIS1 is required for the decidualization in human endometrial stromal cell[J]. J Mol Endocrinol, 2020, 64(4):249-258. doi: 10.1530/JME-19-0100. doi: 10.1530/JME-19-0100
[22]	Alauddin M, Salker MS, Umbach AT, et al. Annexin A7 Regulates Endometrial Receptivity[J]. Front Cell Dev Biol, 2020, 8:770. doi: 10.3389/fcell.2020.00770. doi: 10.3389/fcell.2020.00770 pmid: 32923441
[23]	Zhou M, Xu H, Zhang D, et al. Decreased PIBF1/IL6/p-STAT3 during the mid-secretory phase inhibits human endometrial stromal cell proliferation and decidualization[J]. J Adv Res, 2021, 30:15-25. doi: 10.1016/j.jare.2020.09.002. doi: 10.1016/j.jare.2020.09.002
[24]	Tong J, Yang J, Lv H, et al. Dysfunction of pseudogene PGK1P2 is involved in preeclampsia by acting as a competing endogenous RNA of PGK1[J]. Pregnancy Hypertens, 2018, 13:37-45. doi: 10.1016/j.preghy.2018.05.003. doi: 10.1016/j.preghy.2018.05.003
[25]	Ma LN, Huang XB, Muyayalo KP, et al. Lactic Acid: A Novel Signaling Molecule in Early Pregnancy?[J]. Front Immunol, 2020, 11:279. doi: 10.3389/fimmu.2020.00279. doi: 10.3389/fimmu.2020.00279
[26]	Liu H, Huang X, Mor G, et al. Epigenetic modifications working in the decidualization and endometrial receptivity[J]. Cell Mol Life Sci, 2020, 77(11):2091-2101. doi: 10.1007/s00018-019-03395-9. doi: 10.1007/s00018-019-03395-9
[27]	Kim TH, Yoo JY, Choi KC, et al. Loss of HDAC3 results in nonreceptive endometrium and female infertility[J]. Sci Transl Med, 2019, 11(474):eaaf7533. doi: 10.1126/scitranslmed.aaf7533. doi: 10.1126/scitranslmed.aaf7533
[28]	Long J, Yang CS, He JL, et al. FOXO3a is essential for murine endometrial decidualization through cell apoptosis during early pregnancy[J]. J Cell Physiol, 2019, 234(4):4154-4166. doi: 10.1002/jcp.27167. doi: 10.1002/jcp.27167
[29]	Kelleher AM, Behura SK, Burns GW, et al. Integrative analysis of the forkhead box A2 (FOXA2) cistrome for the human endometrium[J]. FASEB J, 2019, 33(7):8543-8554. doi: 10.1096/fj.201900013R. doi: 10.1096/fj.201900013R pmid: 30951376
[30]	Quenby S, Vince G, Farquharson R, et al. Recurrent miscarriage: a defect in nature′s quality control?[J]. Hum Reprod, 2002, 17(8):1959-1963. doi: 10.1093/humrep/17.8.1959. doi: 10.1093/humrep/17.8.1959