Abstract:

Insulin resistance (IR) is not only one of the important cause of various metabolic diseases, but also an important factor affecting female reproductive function. In recent years, more and more attention has been paid to the effect of IR on female reproductive function by scholars at home and abroad, and a series of studies on the influence of IR on female reproductive function have been carried out from different angles and levels. By disturbing the function of mitochondria of oocyte, destroying the balance of oxidation and antioxidation, producing inflammatory factors, the oocyte quality decreases, the damage of mitochondrial function aggravates IR, and the oocyte quality further decreases, which is a vicious circle. IR reduces endometrial receptivity and ultimately leads to reduced fertility by affecting endometrial energy metabolism, expression of AMPK pathway and PI3K/Akt pathway molecules, chronic inflammatory state and expression of other micro molecules. In addition, a variety of adverse pregnancy outcomes and pregnancy complications are also related to IR. For example, IR is a risk factor for spontaneous abortion, and pre-pregnancy IR will increase the incidence of gestational diabetes, as well as the risk of glucose intolerance, macrocephaly, obesity and hypertension in offspring.

Key words: Insulin resistance, Oocyte, Endometrium, Signal transduction, Pregnancy outcome