Progress in Clinical Treatment of Menstrual Blood Stem Cell-Derived Exosomes

doi:10.12280/gjfckx.20210181

Abstract

Abstract:

Menstrual blood stem cell-derived exosomes (MenSC-Ex) showed unique charm to researchers by advantages such as non-invasive obtaining procedure, no ethical problems and low immunogenicity. The therapeutic potential and underlying mechanisms were investigated in a series of diseases, showing positive resultes. Recent studies have found that MenSC-Ex can enhance tissue regeneration by limiting inflammatory response and inhibiting autoimmunity. It can also regulate the production of various cytokines such as angiopoietin and interleukin-6 through paracrine and other pathways to assist tissue repair. By targeting the reactive oxygen species and other pathways, MenSC-Ex can also affect the synthesis of vascular endothelial growth factor in cancer cells so as to regulate tumor angiogenesis and subsequently have an impact on tumor process. In the aspect of reproductive medicine, MenSC-Ex has shown promising effect of promoting embryonic development to improve the outcome of in vitro fertilization, and also promoting follicular development to restore ovarian function. In addition, its unique nano-lipid bilayer structure makes it possible for MenSC-Ex to be applied as an efficient nanoparticle delivery system, bearing drugs and biomolecules, which could transfer through the biological barriers and play therapeutic role at the targeted site. In this paper, we made a systemic review on the biological features and working mechanism of MenSC and MenSC-Ex, emphasizing on the clinical application of MenSC-Ex. Future research directions and innovative strategies were expounded as well.

Key words: Menstrual blood, Endometrium, Stem cells, Exosomes, Therapy

LIU Bo-tong, LIU Dong-zhe, CHEN Xiu-hui. Progress in Clinical Treatment of Menstrual Blood Stem Cell-Derived Exosomes[J]. Journal of International Obstetrics and Gynecology, 2021, 48(5): 592-596.

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