Research Advance of Biocomposite Materials in Promoting Endometrial Regeneration

doi:10.12280/gjfckx.20200948

Abstract

Abstract:

Intrauterine adhesion (IUA) is a fibrosis repair disorder caused by endometrial injury, and may be accompanied by menstrual abnormalities and lead to infertility. The current mainstream clinical treatments have varying degrees of limitations. For example, mechanical damage and high inflammatory conditions caused by surgery may further aggravate the severity of fibrosis and bring adverse pregnancy outcomes. And there are also low retention rates for local drug treatment and stem cell therapy leading to poor effect of promoting endometrial regeneration. Tissue engineering to promote endometrial regeneration is a novel and promising idea that has been widely studied. The biocompatible materials as a carrier to deliver drugs or stem cells into the uterine cavity which are released slowly have good therapeutic effects. Among them, there are few reports of biocomposites in the treatment of IUA, but the effect is significant. Now, biocomposites using by the tissue engineering methods to promote endometrial regeneration will be reviewed as follow.

Key words: Tissue adhesions, Uterus, Endometrium, Regeneration, Biocompatible materials, Stents, Tissue engineering

LI Wen-zhu, XU Bu-fang. Research Advance of Biocomposite Materials in Promoting Endometrial Regeneration[J]. Journal of International Obstetrics and Gynecology, 2021, 48(3): 290-294.

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