Potential Role of Autophagy in the Pathogenesis of Chronic Endometritis

doi:10.12280/gjfckx.20210984

Abstract

Abstract:

Chronic endometritis (CE) can lead to infertility, recurrent pregnancy loss and recurrent implantation failure. The specific pathogenesis mechanism of CE remains unknown. Abnormal autophagy was proved in the endometrium of patients with CE, indicating that autophagy plays an important role in the development of CE. Researches have confirmed that the development of CE is related with abnormal distribution and polarization of macrophages, as well as abnormal activation of NOD-like receptor protein 3 (NLRP3) inflammasome, both of which are modulated by autophagy. Thus, we propose that autophagy may activate NLRP3 inflammasome by regulating macrophage polarization, thereby leading to the occurrence of CE. This review illustrates a new insight for the pathogenesis of CE and provides new potential targets for the treatment of CE.

Key words: Autophagy, Macrophages, NLR family,pyrin domain-containing 3 protein, Endometritis, Chronic endometritis

WANG Xing, YANG Ru-yu, SITU Xiao-hua, LIANG Yan-chun. Potential Role of Autophagy in the Pathogenesis of Chronic Endometritis[J]. Journal of International Obstetrics and Gynecology, 2022, 49(3): 246-249.

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