Abstract:

Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility. Ovulation induction is the first choice of treatment for PCOS patients with fertility requirements. According to the current domestic and international treatment guidelines, clomiphene citrate (CC) is the traditional first-line drug to induce ovulation for infertile women with PCOS. However, the response of CC ovulation treatment varies significantly for different patients. It was reported that about 40% of PCOS patients cannot respond to CC, that is, CC resistance. This paper provides a review on the research progress of predictive indicators for PCOS infertile women with CC resistance as well as alternative ovulation induction strategies in recent years. This paper mainly expounds the predictive indicators for PCOS patients with CC resistance from the perspective of phenotype, biochemical characteristics and genetics. Single or combined schemes are selected in the treatment methods of letrozole (LE), gonadotropin (Gn), laparoscopic ovarian perforation (LOD), in vitro fertilization (IVF) and adjunctive therapy of traditional Chinese medicine to elaborate their alternative ovulation induction strategies, and the advantages and potential shortcomings of these single and combined schemes are discussed to provide more accurate and individualized ovulation induction schemes for PCOS infertile women.

Key words: Polycystic ovary syndrome, Infertility,female, Clomiphene, Ovulation induction, Therapy