Research Progress of Fibroblast Growth Factor 21 and Gestational Metabolic Diseases

doi:10.12280/gjfckx.20230156

Abstract

Abstract:

Gestational metabolic diseases (GMD) are the most common cause of maternal and neonatal outcomes, but the mechanism remains unclear. Fibroblast growth factor 21 (FGF21) is a polypeptide hormone synthesized by a variety of organs. Its mechanism of action is complex. It regulates a series of metabolic processes in vitro and in vivo, and mainly participates in metabolic activities such as glucose, lipid, energy regulation and hepato-intestinal circulation of bile acid by means of endocrine. It also plays a key role in cell proliferation and differentiation, neuronal development, angiogenesis and wound healing. Therefore, FGF21 release disorders, signal dysregulation, and abnormal function are closely associated with GMD such as gestational diabetes mellitus, gestational hypertension disease, and intrahepatic cholestasis of pregnancy. This article reviews the latest research progress on the mechanism of FGF21 in GMD, so as to identify GMD and its hidden disease as early and accurate as possible, achieve the purpose of early diagnosis and intervention, and ultimately improve the prognosis of mothers and infants.

Key words: Fibroblast growth factor 21, Metabolism, Diabetes, gestational, Hypertension, pregnancy-induced, Cholestasis, intrahepatic

LI Jing-jing, SUN Xiao-tong, LIU Ting-ting, LI Zhen-ying, ZHANG Yi-fan, SU Yan. Research Progress of Fibroblast Growth Factor 21 and Gestational Metabolic Diseases[J]. Journal of International Obstetrics and Gynecology, 2023, 50(4): 400-404.

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