Mechanism Study of MAPK Pathway in PCOS and Monomeric Treatment of Traditional Chinese Medicine

doi:10.12280/gjfckx.20240713

Abstract

Abstract:

Polycystic ovary syndrome (PCOS) is a common and complex gynecological endocrine disorder that mainly affects women of childbearing age. Its main characteristics include ovulation disorders, insulin resistance and hyperandrogenemia. The mitogen-activated protein kinase (MAPK) signaling pathway plays an important role in the occurrence of PCOS. It has been confirmed that the three classic MAPK pathways - extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 MAPK are closely related to the occurrence of PCOS. Once these pathways are abnormally activated, it will prompt the body to have a variety of adverse reactions and ultimately lead to PCOS. Specifically, it includes ovulation dysfunction, insulin resistance, elevated androgen levels, oxidative stress and inflammatory reactions. Studies have shown that a variety of traditional Chinese medicine monomers can regulate the activity and expression of MAPK signaling pathway-related proteins. These traditional Chinese medicine monomers include flavonoids, glycosides, terpenoids, alkaloids and polysaccharides. Through this modulation, they can effectively improve the pathophysiological process of PCOS patients, thus providing new ideas and methods for the treatment of PCOS.

Key words: Polycystic ovary syndrome, Mitogen-activated protein kinases, Traditional Chinese medicine monomers, Insulin resistance, Hyperandrogenism

HU Die, REN Jia-jie, LIU Jia-ning, FENG Xiao-ling. Mechanism Study of MAPK Pathway in PCOS and Monomeric Treatment of Traditional Chinese Medicine[J]. Journal of International Obstetrics and Gynecology, 2024, 51(6): 684-691.

Figures/Tables 2

References 46

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中药单体	单体类别	检测指标	作用机制	参考文献
葛根素	黄酮类	雌激素、孕酮、LH/FSH、p-ERK1/2、p-JNK、Caspase-3、Bax↓，Bcl-2↑	调节激素水平，减少细胞凋亡	[32]
木犀草素及其类似物木犀草素-7-甲基醚	黄酮类	p-TPL2、p-MMK3/6、p-p38 MAPK、p-CREB、空腹血清胰岛素水平、LH↓，FSH、雌二醇↑	改善过多雌激素生物合成和高胰岛素水平	[33]
山楂叶黄酮	黄酮类	FINS、FBG、HOMA-IR、p-p38 MAPK、p-STAT3↓，FSH、孕酮、雌二醇↑，IL-6、TNF-α↓	调节激素平衡，减弱IR，减少炎症反应	[35]
菟丝子总黄酮	黄酮类	FINS、HOMA-IR、TSH、p-p38 MAPK、p-ERK↓，FSH、雌二醇、T3、T4↑	改善排卵障碍，调节血清甲状腺激素水平，减弱IR	[36]
黄芪甲苷	苷类	LH、睾酮、FBG、FINS、LH/FSH、HOME-IR、p-p38 MEK、p-ERK、p-Raf↓，雌二醇↑，MDA↓，GSH、SOD↑，Caspase-3、Bax↓，Bcl-2↑	缓解IR，减少氧化应激损害，抑制细胞凋亡	[38-39]
青蒿琥酯	萜类	IL-1β、IL-18、TNF-α、p-p38 MAPK、p-NF-κB p65↓	减轻炎症反应	[41]
黄连素	生物碱类	LH、睾酮、LH/FSH、p-p38 MAPK、p-JNK↓	调节激素水平	[43]
茯苓多糖	多糖类	FBG、FINS、三酰甘油、HOMA-IR、MDA、p-p38 MAPK、p-JNK↓，ISI、GSH-Px、SOD↑	减轻IR，保护细胞免受氧化应激损伤	[46]

中药单体	单体类别	检测指标	作用机制	参考文献
葛根素	黄酮类	雌激素、孕酮、LH/FSH、p-ERK1/2、p-JNK、Caspase-3、Bax↓，Bcl-2↑	调节激素水平，减少细胞凋亡	[32]
木犀草素及其类似物木犀草素-7-甲基醚	黄酮类	p-TPL2、p-MMK3/6、p-p38 MAPK、p-CREB、空腹血清胰岛素水平、LH↓，FSH、雌二醇↑	改善过多雌激素生物合成和高胰岛素水平	[33]
山楂叶黄酮	黄酮类	FINS、FBG、HOMA-IR、p-p38 MAPK、p-STAT3↓，FSH、孕酮、雌二醇↑，IL-6、TNF-α↓	调节激素平衡，减弱IR，减少炎症反应	[35]
菟丝子总黄酮	黄酮类	FINS、HOMA-IR、TSH、p-p38 MAPK、p-ERK↓，FSH、雌二醇、T3、T4↑	改善排卵障碍，调节血清甲状腺激素水平，减弱IR	[36]
黄芪甲苷	苷类	LH、睾酮、FBG、FINS、LH/FSH、HOME-IR、p-p38 MEK、p-ERK、p-Raf↓，雌二醇↑，MDA↓，GSH、SOD↑，Caspase-3、Bax↓，Bcl-2↑	缓解IR，减少氧化应激损害，抑制细胞凋亡	[38-39]
青蒿琥酯	萜类	IL-1β、IL-18、TNF-α、p-p38 MAPK、p-NF-κB p65↓	减轻炎症反应	[41]
黄连素	生物碱类	LH、睾酮、LH/FSH、p-p38 MAPK、p-JNK↓	调节激素水平	[43]
茯苓多糖	多糖类	FBG、FINS、三酰甘油、HOMA-IR、MDA、p-p38 MAPK、p-JNK↓，ISI、GSH-Px、SOD↑	减轻IR，保护细胞免受氧化应激损伤	[46]