Abstract:

A case of a rare non-human papilloma virus (HPV)-related mesonephric adenocarcinoma (MNA) of the cervix is reported, and its clinical diagnosis and treatment characteristics, pathological features, and causes of misdiagnosis are analyzed in depth. The patient was a postmenopausal woman with no obvious clinical symptoms, and the previous cervical HPV and thin-prep cytology test results were both negative. She suddenly had vaginal bleeding 2 years after menopause. Clinical physical examination showed that the cervix looked normal, but the uterus was significantly enlarged. At the initial diagnosis, it was misdiagnosed as endometrial cancer. After the surgery, the diagnosis of cervical malignant tumor was confirmed by histopathological examination, and MNA was diagnosed by immunohistochemical analysis. This case emphasizes the crucial role of multi-disciplinary collaboration in the diagnosis and treatment of non-HPV-related cervical adenocarcinoma. It prompts clinicians to pay more attention to patients with atypical symptoms, comprehensively use means such as medical history collection, laboratory tests, imaging evaluation, and pathological analysis, broaden the diagnostic thinking, and strengthen the multidisciplinary collaboration mechanism, so as to reduce the misdiagnosis rate and promote the precise diagnosis and treatment of non-HPV-related cervical adenocarcinoma.

Key words: Papillomaviridae, Lymphatic metastasis, Diagnostic errors, Mesonephric adenocarcinoma, Cervical adenocarcinoma