Abstract: Objective：To investigate the effect of compound salvia miltiorrhiza injection on early onset severe pre-eclampsia patients and their neonatals. Methods：Total 130 patients diagnosed with early onset severe pre-eclampsia between March 2013 and March 2015 in Baoji Maternal and Child Care Service Centre were randomly divided into compound salvia miltiorrhiza injection group (67 cases) and control group (63 cases). Control group patients gave spasmolysis, calm, step-down diuresis, appropriate and dexamethasone to promote fetal lung maturity, high-protein low-fat diet routine therapy, salvia miltiorrhiza group patients gave compound salvia miltiorrhiza injection on the basis of control group treatment, both groups of patients were treated with two weeks. Nitric oxide, endothelin-1(ET-1), TNF-α and IL-6 levels were detected and compared before and after treatment in two groups. And also, the blood pressure before and after the treatment, childbirth neonatal gestational age, postpartum neonatal deaths, quality of the placenta, survival neonatal weight and 1 min Apgar score were compared between two groups. Results：The indicators of the two groups of patients had no statistical differences before treatment (P＞0.05). ET-1, ET-1/NO, TNF-α, IL-6 levels, systolic pressure, diastolic pressure and mean arterial pressure were reduced by two treatment methods in early onset severe pre-eclampsia patients, nitric oxide was elevated significantly (P＜0.05). The degree of changes in ET-1, ET-1/NO, TNF-α, IL-6 and nitric oxide in compound salvia miltiorrhiza injection group before and after treatment were greater than control group (P＜0.001). Salvia miltiorrhiza treatment group neonatal mortality is lower than the control group, to those who gave live births, childbirth neonatal gestational age was longer in the salvia miltiorrhiza group (P＜0.001). Quality of the placenta, neonatal weight, quality of the placenta and 1 min Apgar score in survival subjects were improved in compound salvia miltiorrhiza injection group than control group (P＜0.001). Conclusions：Compound salvia miltiorrhiza injection improved prognosis of early onset severe pre-eclampsia patients by mechanism of anti-inflammation and regulation of endothelial function.

Key words: Danshen injection, Pre-eclampsia, Endothelin-1, Tumor necrosis factor-alpha, Interleukin-6, Blood pressure