Abstract: Autophagy is a biology process that recycle the macromolecular substances and maintain cell stability by self digestion. The change of autophagic activity, autophagic cell death are related to genesis and development of malignancy. ARHI, one of the autophagy related gene, may play a part in the occurrence and progress of tumor through regulating autophagic capacity. The key kinase in signaling pathways that ARHI regulates autophagic capacity may provide new drug targets for cancer treatment. This review summarized the present studies of ARHI, autophagy and their correlation with the occurrence and development of tumor.

Key words: Autophagy, Neoplasms, Genes, Cell death, ARHI