Abstract: Endometrial carcinoma（EC） is one of three most common malignant female genital carcinomas. The incidence of EC has been increased recently. Although it occurs mainly in the postmenopausal women，there are still 25% patients are pre-menopausal and 3%-14% patients are below 40 years old. It is hard for the younger nulliparous patients to accept the fact that they may lose their ability to give birth and the endocrine function of the ovaries. Thus，to preserve the fertility and endocrine function of the ovaries for the younger EC patients will be the attention problem. Recent years，present study indicates that primary treatment with megestrol acetate may be an effective and relatively safe choice of treatment of women with well-differentiated endometrial adenocarcinoma who wish to preserve the function of reproductive endocrinology. This article reviewed current literature of fertility and ovary function preservation treatment for those young patients with EC.

Key words: Endometrial neoplasms, Fertility, Ovary, Reproductive technology, assisted, Therapy