Expression and Clinical Significance of CD147，MCT1 and MCT4 in Cervical Lesions

Abstract

Abstract: Objective： To study the expression aｎｄｃｌｉｎｉｃａｌｓｉｇｎｉｆｉｃａｎｃｅｏｆＣＤ１４７，ｍｏｎｏｃａｒｂｏｘｙｌａｔｅｔｒａｎｓｐｏｒｔｅｒｓ１（ＭＣＴ１）ａｎｄＭＣＴ４ｉｎｃｅｒｖｉｃａｌｌｅｓｉｏｎｓａｎｄｃｅｒｖｉｃａｌｃａｎｃｅｒ．Ｍｅｔｈｏｄｓ：Ｃｈｏｏｓｅ９２ｐａｔｉｅｎｔｓｗｉｔｈｃｅｒｖｉｃａｌｌｅｓｉｏｎｓ，ｉｎｃｌｕｄｉｎｇ４３ｃａｓｅｓｏｆｃａｒｃｉｎｏｍａｏｆｔｈｅｃｅｒｖｉｘ（ｃｅｒｖｉｃａｌｃａｎｃｅｒｇｒｏｕｐ），３４ｃａｓｅｓｗｉｔｈＣＩＮ（ＣＩＮｇｒｏｕｐ，１２ｃａｓｅｓｏｆＣＩＮⅠ，１１ｃａｓｅｓｏｆＣＩＮⅡ，１１ｃａｓｅｓｏｆＣＩＮⅢ），１５ｃａｓｅｓｏｆｎｏｒｍａｌｃｅｒｖｉｃａｌａｓｃｏｎｔｒｏｌｓ（ｃｏｎｔｒｏｌｇｒｏｕｐ）．ＩｍｍｕｎｏｈｉｓｔｏｃｈｅｍｉｓｔｒｙｗａｓｕｓｅｄｔｏｔｅｓｔａｎｄａｎａｌｙｚｅｔｈｅｅｘｐｒｅｓｓｉｏｎｏｆＣＤ１４７，ＭＣＴ１ａｎｄＭＣＴ４．Ｒｅｓｕｌｔｓ：ＴｈｅｐｏｓｉｔｉｖｅｅｘｐｒｅｓｓｉｏｎｒａｔｅｓｏｆＣＤ１４７，ＭＣＴ１ａｎｄＭＣＴ４ｉｎｃｅｒｖｉｃａｌｃａｎｃｅｒｇｒｏｕｐｗａｓｈｉｇｈｅｒｔｈａｎｔｈａｔｉｎＣＩＮｇｒｏｕｐ（ａｌｌＰ＜０．０５）ａｎｄｃｏｎｔｒｏｌｇｒｏｕｐ（ａｌｌＰ＜０．０５）．ＣＩＮｇｒｏｕｐｗａｓｈｉｇｈｅｒｔｈａｎｃｏｎｔｒｏｌｇｒｏｕｐ（ａｌｌＰ＜０．０５），ＣＩＮⅡ－Ⅲ ｇｒｏｕｐｗａｓｈｉｇｈｅｒｔｈａｎＣＩＮⅠ ｇｒｏｕｐ（ａｌｌＰ＜０．０５）．Ｉｎｃｅｒｖｉｃａｌｃａｒｃｉｎｏｍａｇｒｏｕｐ，ｔｈｅｐｏｓｉｔｉｖｅｅｘｐｒｅｓｓｉｏｎｒａｔｅｓｏｆＣＤ１４７ａｎｄＭＣＴ１ｉｎａｇｅ≤３５ｙｅａｒｓｏｌｄｇｒｏｕｐｗａｓｌｏｗｅｒｔｈａｎｔｈａｔｉｎｔｈｅｇｒｏｕｐｏｆａｇｅ＞３５ｙｅａｒｓｏｌｄｇｒｏｕｐ，ｔｈａｔｏｆｓｔａｇｅ Ⅰ－Ⅱ ｇｒｏｕｐｉｓｌｏｗｅｒｔｈａｎｓｔａｇｅ Ⅲ－Ⅳ，ａｎｄｔｈａｔｏｆｈｉｇｈｄｉｆｆｅｒｅｎｔｉａｔｉｏｎｇｒｏｕｐｗａｓｌｏｗｅｒｔｈａｎｔｈａｔｉｎｌｏｗｄｉｆｆｅｒｅｎｔｉａｔｉｏｎｇｒｏｕｐ（ａｌｌＰ＜０．０５）．Ｉｎｃｅｒｖｉｃａｌｃａｒｃｉｎｏｍａｇｒｏｕｐ，ｔｈｅｐｏｓｉｔｉｖｅｅｘｐｒｅｓｓｉｏｎｒａｔｅｓｏｆＭＣＴ４ｉｎａｇｅｄ≤３５ｙｅａｒｓｏｌｄｇｒｏｕｐｗａｓｌｏｗｅｒｔｈａｎｔｈａｔｉｎｔｈｅｇｒｏｕｐｏｆａｇｅ＞３５ｙｅａｒｓｏｌｄｇｒｏｕｐ，ａｎｄｔｈａｔｏｆｈｉｇｈｄｉｆｆｅｒｅｎｔｉａｔｉｏｎｇｒｏｕｐｗａｓｌｏｗｅｒｔｈａｎｔｈａｔｉｎｌｏｗｄｉｆｆｅｒｅｎｔｉａｔｉｏｎｇｒｏｕｐ（ａｌｌＰ＜０．０５）．Ｄｉｆｆｅｒｅｎｃｅｓｂｅｔｗｅｅｎｓｔａｇｅ Ⅰ－Ⅱ ｇｒｏｕｐａｎｄｓｔａｇｅ Ⅲ－Ⅳ ｇｒｏｕｐｈａｄｎｏｓｔａｔｉｓｔｉｃａｌｓｉｇｎｉｆｉｃａｎｃｅ．ＴｈｅｒｅｗａｓｓｔａｔｉｓｔｉｃａｌｌｙｓｉｇｎｉｆｉｃａｎｔｃｏｎｓｉｓｔｅｎｃｙｂｅｔｗｅｅｎｔｈｅｅｘｐｒｅｓｓｉｏｎｏｆＭＣＴ１ａｎｄＣＤ１４７（ｗｅｉｇｈｔｅｄＫａｐｐａ＝０．７７４，Z＝１０．１２６，Ｐ＜０．００１）．ＴｈｅｒｅｗａｓｓｔａｔｉｓｔｉｃａｌｌｙｓｉｇｎｉｆｉｃａｎｔｃｏｎｓｉｓｔｅｎｃｙｂｅｔｗｅｅｎＭＣＴ４ａｎｄＣＤ１４７（ｗｅｉｇｈｔｅｄＫａｐｐａ＝０．９０９，Z＝１１．６２８，Ｐ＜０．００１）．ＴｈｅｒｅｗａｓｓｔａｔｉｓｔｉｃａｌｌｙｓｉｇｎｉｆｉｃａｎｔｃｏｎｓｉｓｔｅｎｃｙｂｅｔｗｅｅｎＭＣＴ１ａｎｄＭＣＴ１（ｗｅｉｇｈｔｅｄＫａｐｐａ＝０．７９７，Z＝１０．３８３，Ｐ＜０．００１）．Ｃｏｎｃｌｕｓｉｏｎｓ：ＴｈｅｅｘｐｒｅｓｓｉｏｎｏｆＣＤ１４７，ＭＣＴ１，ＭＣＴ４ｗｅｒｅｃｏｎｓｉｓｔｅｎｔｌｙｈｉｇｈｅｒｌｅｖｅｌｉｎｃｅｒｖｉｃａｌｌｅｓｉｏｎｓａｎｄｐｌａｙｉｍｐｏｒｔａｎｔｒｏｌｅｓｉｎｔｈｅｄｅｖｅｌｏｐｍｅｎｔｏｆＣＩＮａｎｄｃｅｒｖｉｃａｌｃａｒｃｉｎｏｍａ．ＴｈｅｙｃａｎｂｅａｃｃｅｐｔｅｄａｓｔｈｅｏｂｊｅｃｔｉｖｅｌｙｈｉｇｈｒｉｓｋｉｎｄｅｘｅｓｉｎｐｒｏｇｒｅｓｓｉｏｎｆｒｏｍｌｏｗｌｅｖｅｌｔｏｈｉｇｈｌｅｖｅｌｏｆＣＩＮａｎｄｃｅｒｖｉｃａｌｃａｎｃｅｒ．ＬｏｗａｎｄｈｉｇｈｌｅｖｅｌＣＩＮｗｉｔｈｈｉｇｈｅｘｐｒｅｓｓｉｏｎｏｆＣＤ１４７，ＭＣＴ１ａｎｄＭＣＴ４ｓｈｏｕｌｄｂｅｇｉｖｅｎａｃｔｉｖｅｔｒｅａｔｍｅｎｔａｎｄｆｏｌｌｏｗｅｄ－ｕｐ．

Key words: Uterine cervical neoplasms, Cervical intraepithelial neoplasia, Immunohistochemistry, Antigens, CD147, Monocarboxylate transporter

ZHANG Bao-yue;QU Quan-xin;GU An-kang. Expression and Clinical Significance of CD147，MCT1 and MCT4 in Cervical Lesions[J]. Journal of International Obstetrics and Gynecology, 2015, 42(2): 194-196.

[1]	GUO Jing, ZHANG Mao-xiang, ZHOU Chun-he, LIU Si-ning, LI Hui-yan. The Progress of Mendelian Randomization in the Study of the Causal Relationship between Exposure Factors and Cervical Cancer [J]. Journal of International Obstetrics and Gynecology, 2025, 52(2): 169-174.
[2]	CHAI Ling-na, LI Yan-li, SHI Jie, GAO Han, OUYANG Xi-yan, CHENG Shi-yu. Clinical Application of Indocyanine Green Tracing of Sentinel Lymph Nodes in Early Cervical Cancer [J]. Journal of International Obstetrics and Gynecology, 2025, 52(2): 175-179.
[3]	CHEN Shu-wan, DENG Gao-pi, YUAN Shuo. A Case of Uterine Leiomyoma with Bizarre Nucleus [J]. Journal of International Obstetrics and Gynecology, 2025, 52(2): 187-190.
[4]	BAI Yao-jun, WANG Si-yao, LING Fei-fei, ZHANG Sen-huai, LI Hong-li, LIU Chang. Progress of Trop-2 and Targeted Trop-2 Antibody-Coupled Drugs in Gynecological Malignant Tumors [J]. Journal of International Obstetrics and Gynecology, 2025, 52(1): 1-7.
[5]	HU Ming-zhu, LIU Li-wen, HUANG Lei. The Relationship between Vaginal Microecology and Cervical Cancer in HIV-Infected Women [J]. Journal of International Obstetrics and Gynecology, 2025, 52(1): 13-18.
[6]	ZHANG Ye, CHEN Qiao-yun, ZHAO Jia-yi, CHEN Lu, LIU Jian-rong. Progress in the Application of Nanoparticles in the Prevention and Treatment of Cervical Cancer [J]. Journal of International Obstetrics and Gynecology, 2025, 52(1): 8-12.
[7]	WEI Jin-hua, QI Yu-chao, SHEN Xiao-ya. Analysis on the Incidence and Mortality of Cervical Cancer in China Based on the Age-Period-Cohort Model from 1992 to 2021 [J]. Journal of International Obstetrics and Gynecology, 2024, 51(6): 664-668.
[8]	LIU Yu, WU Rui-fang, LI Rui-zhen. A Case Report of Pregnancy after Radical Cervicectomy with Neoadjuvant Chemotherapy in Stage ⅠB2 Cervical Cancer [J]. Journal of International Obstetrics and Gynecology, 2024, 51(6): 669-671.
[9]	SONG Han, LIU Han-li, WANG Xi-bo. A Case of Soft Tissue Metastasis in the Back from Cervical Cancer [J]. Journal of International Obstetrics and Gynecology, 2024, 51(6): 672-675.
[10]	LI Hui-min, HU Ya-li, ZHANG Sen-huai, MA Xiao-mei, XU Fei-xue. Progress in the Application of High Intensity Focused Ultrasound Technology in Obstetric and Gynecological Diseases [J]. Journal of International Obstetrics and Gynecology, 2024, 51(5): 486-491.
[11]	JIN Xiao-lei, XU Fei-xue. Five Cases of Diagnosis and Treatment of Ovarian Brenner Tumors [J]. Journal of International Obstetrics and Gynecology, 2024, 51(5): 578-583.
[12]	WANG Jing, WANG Xiao-hui. Cervical Carcinosarcoma：A Case Report and Literature Review [J]. Journal of International Obstetrics and Gynecology, 2024, 51(5): 597-600.
[13]	ZHANG Lan-yue, SHEN Fu-jin. Research Progress of Adoptive Cell Immunotherapy in Cervical Cancer [J]. Journal of International Obstetrics and Gynecology, 2024, 51(3): 253-257.
[14]	ZHANG Wen, WANG Xue-qian, SHI Yu-xiang, HUANG Zeng-fa, TIAN Xun. A Case Report of Cervical Adenoid Cystic Carcinoma Combined with Basal Cell Carcinoma and Squamous Cell Carcinoma [J]. Journal of International Obstetrics and Gynecology, 2024, 51(3): 258-262.
[15]	SU Rui-rui, WU Xiao-hong. Impact of Cervical Conization on Fertility and Pregnancy Outcomes and Improve Measures [J]. Journal of International Obstetrics and Gynecology, 2024, 51(3): 317-321.

Expression and Clinical Significance of CD147，MCT1 and MCT4 in Cervical Lesions

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments