Table of Content

15 April 2015, Volume 42 Issue 2
Previous Issue    Next Issue
---
综述
论著
综述
论著
综述
论著
标准与指南


For Selected:

Download Citations EndNote Ris BibTeX

Toggle Thumbnails

综述

Select

Research Progress of miR-124 in Gynecological Malignant Tumors LIU Fang-li;HAO Min;ZHAO Wei-hong 2015, 42 (2):  125-128.  Abstract ( 1043 )   PDF (800KB) ( 5353 )   MicroRNA (miRNA) are endogenous single-stranded noncoding RNA, which generating the role of transcriptional silencing by complementary binding to the target genes. In recent years, a large number of studies have shown that the occurrence of wide variety of tumor associated with abnormal expression of miR-124, which plays an important role in inhibiting of cell proliferation, promoting apoptosis and inhibiting the invasion and metastasis of tumor. Researches have revealed that miR-124 is remarkably down-regulated in many tumor cells and ontic tissues, and is closely related to the occurrence and development of tumor. In recent years, the study of the role of miR-124 in gynecological malignant tumor is increasing, but its mechanism still need further research. This article elaborates biological function of miR-124 and improvements of studies in gynecological malignant tumors. Related Articles | Metrics

Select

Progress of the Correlation about Matriptase and the Invasion and Metastasis of Endometrial Cancer XUE Li-fang;SUN Peng-ming;XIANG Shuang-wei 2015, 42 (2):  129-132.  Abstract ( 951 )   PDF (577KB) ( 5498 )   Invasion and metastasis is one of the important biological features of malignant tumor, which leads to the cancer patients deaths. Tumor invasion and metastasis is a complex pathological process involving many kinds of protease which including metal matrix protease, serine protease and so on. Recently, we found a type Ⅱ transmembrane serine protease named Matriptase which can enhance the process of tumor invasion and metastasis through activating urokinase-type plasminogen activator, hepatocyte growth factor/scatter factor, protease activated receptor 2 and prostate. It was closely related to the occurrence and development of a variety of malignant tumors, such as breast cancer, esophageal cancer, prostate cancer, cervical cancer, ovarian cancer and endometrial cancer. Thus, Matriptase is expected to become a new biomarker for tumor diagnosis and a promising treatment target. Now we will discuss the correlation about Matriptase and the invasion and metastasis of endometrial cancer. Related Articles | Metrics

Select

Research of the Correlation between Lipid Metabolic and Endometrial Cancer SHI Rui;WANG Hong-bo 2015, 42 (2):  133-135.  Abstract ( 1035 )   PDF (388KB) ( 5429 )   In plasma lipids are collectively referred to as lipid, including triglycerides, phospholipid, cholesterol and the ester, free fatty acids, etc. Lipid metabolism disorder is generally elevated triglycerides（ＴＧ） and low high-density lipoprotein cholesterol（HDL-C）. Since leptin found in 1994, people begin to discover the roles except the traditional ones of lipid metabolism（such as energy, synthetic hormones, etc.）. Many studies suggest the correlations between lipid metabolism and cardiovascular diseases, malignant tumors. Researchers found that elevated triglycerides in the blood plasma associated with the ｐａｔｈｏｇｅｎｅｓｉｓ ｏｆ ｅｎｄｏｍｅｔｒｉａｌ ｃａｒｃｉｎｏｍａ， ｈｏｗｅｖｅｒ， ｔｈｅ ｓｔｕｄｙ ｈａｓ ｎｏｔ ｙｅｔ ｆｏｕｎｄ ｔｈａｔ ｌｏｗ ＨＤＬ－Ｃ ｉｓ ｏｎｅ ｏｆ ｔｈｅ ｐａｔｈｏｇｅｎｅｓｉｓ ｏｆ ｅｎｄｏｍｅｔｒｉａｌ ｃａｎｃｅｒ ｒｉｓｋ ｆａｃｔｏｒｓ． Ｔｈｅ ｃｕｒｒｅｎｔ ｓｔｕｄｉｅｓ ｈａｖｅ ｆｏｕｎｄ ｔｈｅ ｃｏｒｒｅｌａｔｉｏｎｓ ｂｅｔｗｅｅｎ ｌｉｐｉｄ ｍｅｔａｂｏｌｉｃ ｄｉｓｏｒｄｅｒ ａｎｄ ｅｎｄｏｍｅｔｒｉａｌ ｃａｎｃｅｒ． Ｌｉｐｉｄ ｍｅｔａｂｏｌｉｃ ｍａｙ ｅｆｆｅｃｔ ｏｎ ｅｎｄｏｍｅｔｒｉａｌ ｃａｎｃｅｒ ｂｙ ｉｎｓｕｌｉｎ ｒｅｓｉｓｔａｎｃｅ ｔｈａｔ ｐｌａｙｓ ａｎ ｓｉｇｎｉｆｉｃａｎｔ ｒｏｌｅ ｉｎ ｅｎｄｏｍｅｔｒｉａｌ ｃａｎｃｅｒ ｄｅｖｅｌｏｐｍｅｎｔ． Ｓｔｕｄｉｅｓ ｈａｖｅ ｆｏｕｎｄ ｔｈａｔ ｌｉｐｉｄ ｍｅｔａｂｏｌｉｓｍ ｒｅｌａｔｅｄ ｓｕｂｓｔａｎｃｅｓ， ｓｕｃｈ ａｓ ｌｅｐｔｉｎ， ｓｔｅｒｏｌ ｒｅｇｕｌａｔｉｎｇ ｅｌｅｍｅｎｔ ｂｉｎｄｉｎｇ ｐｒｏｔｅｉｎｓ（ＳＲＥＢＰｓ）， ｐｅｒｏｘｉｄａｓｅ ｂｏｄｙ ｇｒｏｗｔｈ ａｃｔｉｖａｔｅｄ ｒｅｃｅｐｔｏｒ（ＰＰＡＲ）， may be related to endometrial cancer. Related Articles | Metrics

Select

MicroRNA and Its Role in Ovarian Cancer LI Ming;JIANG Hua 2015, 42 (2):  136-140.  Abstract ( 936 )   PDF (624KB) ( 5324 )   MicroRNA（miRNA） is a type of small evolutionarily conserved non-coding RNAs of 21-23 nucleotides in length that act as post-transcriptional regulators which involves in fundamental cell processes，such as，differentiation，proliferation and death. Recently，it has become clear that alterations in the expression of miRNAs contribute to the pathogenesis and progression of several human malignancies，such as colorectal cancer, cervical cancer, ovarian cancer, and so on. MiRNAs dysregulated expression plays an important role in ovarian cancer pathogenesis，metastasis， resistance and prognosis. They might be used as a noninvasive diagnostic and prognostic biomarker in ovarian cancer，and provide a new clinical thought for the analysis of chemotherapy drug resistance and individualized therapy. This article reviews the functions of miR-200 families,let-7 families and miR-119a, which are frequently dysregulated in ovarian cancer. Related Articles | Metrics

Select

The Human Epididymis Protein 4 Detection of Early Ovarian Cancer GU Wei;ZUO Xu-lei 2015, 42 (2):  141-144.  Abstract ( 1166 )   PDF (533KB) ( 5418 )   Ovarian cancer threatens women′s lives and health which is one of the three malignant tumors of reproductive tract, its younger trend obvious and mortality rate ranked first. It is a key point to reduce the mortality rate of the patients by improving the detectable rate of the ovarian cancer at early stage. However, the traditional ovarian tumor markers carbohydratｅ ａｎｔｉｇｅｎ １２５ （ＣＡ１２５） ｗｈｉｃｈ ｉｓ ａｐｐｌｉｅｄ ｗｉｄｅｌｙ， ｓｈｏｗｓ ａ ｌｏｗ ｓｅｎｓｉｔｉｖｉｔｙ ａｎｄ ｓｐｅｃｉｆｉｃｉｔｙ ｉｎ ｏｖａｒｉａｎ ｃａｎｃｅｒ ａｎｄ ａｌｓｏ ａｐｐｅａｒｓ ｈｉｇｈ ｌｅｖｅｌ ｉｎ ｂｅｎｉｇｎ ｇｙｎｅｃｏｌｏｇｉｃａｌ ｄｉｓｅａｓｅｓ ｎｏｎｓｐｅｃｉｆｉｃａｌｌｙ， ｔｈｅｒｅｆｏｒｅ， ａ ｈｉｇｈｅｒ ｓｅｎｓｉｔｉｖｉｔｙ ａｎｄ ｓｐｅｃｉｆｉｃｉｔｙ ｄｅｔｅｃｔｉｏｎ ｉｎｄｅｘ ｉｓ ｎｅｅｄｅｄ ｕｒｇｅｎｔｌｙ． Ｉｎ ｒｅｃｅｎｔ ｙｅａｒｓ， ｔｈｅ ｓｅｒｕｍ ｍａｒｋｅｒ ｈｕｍａｎ ｅｐｉｄｉｄｙｍis ｐｒｏｔｅｉｎ ４ （ＨＥ４） ｈａｓ ｂｅｃｏｍｅ ｔｈｅ ｆｏｃｕｓ ｏｆ ｔｈｅ ｅａｒｌｙ ｄｉａｇｎｏｓｉｓ ｏｆ ｏｖａｒｉａｎ ｃａｎｃｅｒ． Ｃｏｍｐａｒｅｄ ｔｏ ＣＡ１２５， ＨＥ４ ｗｅｒｅ ｎｏｔ ｅｘｐｒｅｓｓｅｄ ｉｎ ｍｏｓｔ ｏｆ ｔｈｅ ｏｖａｒｉａｎ ｍａｌｉｇｎａｎｔ ｔｕｍｏｒ ｏｒ ｌｏｗ ｅｘｐｒｅｓｓｉｏｎ， ａｎｄ ｄｅｔｅｃｔｉｏｎ ｏｆ ＨＥ４ ａｌｏｎｅ ｏｒ ｃｏｍｂｉｎｅｄ ＣＡ１２５ ｉｎ ｅａｒｌｙ ｄｉａｇｎｏｓｉｓ ｏｆ ｏｖａｒｉａｎ ｃａｎｃｅｒ， ｃｕｒａｔｉｖｅ ｅｆｆｅｃｔ ａｎｄ ｐｒｏｇｎｏｓｉｓ ｅｖａｌｕａｔｉｏｎ ｏｆ ａｎ ｅｄｇｅ． Ｎｏｗ ＨＥ４ ｈａｓ ｂｅｅｎ ａｐｐｌｉｅｄ ｉｎ ｆｏｒｅｉｇｎ ａｎｄ ｓｏｍｅ ｆｉｒｓｔ－ｃｌａｓｓ ｈｏｓｐｉｔａｌ ｉｎ Ｃｈｉｎａ． Ｔｈｉｓ ｐａｐｅｒ ｒｅｖｉｅｗｓ ｔｈｅ ｄｉｓｃｏｖｅｒｙ ｏｆ ＨＥ４， ｄｅｖｅｌｏｐｍｅｎｔ ａｎｄ ｃｌｉｎｉｃａｌ ａｐｐｌｉｃａｔｉｏｎ ａｎｄ ｏｖａｒｉａｎ ｍａｌｉｇｎａｎｔ ｔｕｍｏｒ ｗｉｔｈ ＣＡ１２５ ｃｏｎｓｔｒｕｃｔｓ ｔｈｅ ｒｉｓｋ of ovarian malignancy algorithm（ＲＯＭＡ）． Related Articles | Metrics

Select

Prevention and Treatment for Chemotherapy-induced Damage to Ovarian Function ZHAO Li-ping;XU Tian-min;YANG Ru-lin;CUI Man-hua 2015, 42 (2):  145-148.  Abstract ( 1206 )   PDF (559KB) ( 5393 )   Chemotherapy is the main treatment for immune diseases and cancer, but chemotherapy drugs may cause ovarian dysfunction in female. Amenorrhea, infertility, vasomotor symptoms, sexual dysfunction, osteoporosis and other problems caused by ovarian dysfunction bring great suffering to the patients. These also impact on patients′ psychosocial and sexual psychology. It is very important to find relevant prevention measures to reduce ovarian damage and meantime retaining reproductive and endocrine function in patients. This article summarize the relevant literature, the protection of ovarian function and fertility methods, for example, GnRH analogues, embryo cryopreservation and oocyte cryopreservation, ovarian tissue cryopreservation, apoptosis inhibition, free radical scavenger, therapy of traditional Chinese medicine are described. Related Articles | Metrics

Select

Advance of Tumor Microenvironment in Cervical Cancer LIU Tian-yu;YAO Shu-zhong 2015, 42 (2):  149-153.  Abstract ( 1053 )   PDF (815KB) ( 5375 )   Cervical cancer is one of the most common malignancy of women，which has caused a serious threat to the health of women. The tumor microenvironment of cervical cancer consists of cancer-associated fibroblasts，tumor associated macrophages，immune cells，extracellular matrix and other ingredients. For HPV positive cervical cancer，one of roles of HPV in promoting cervical carcinogenesis was that HPV activated IL-6/STAT3 signaling. Tumor-associated fibroblasts and tumor-associated macrophages，which are two important cells in the tumor microenvironment，can secret many cytokines and interact with several constituents of tumor microenvironment，and thus facilitating the genesis，development and metastasis of tumor. Moreover，various immune cells，namely Langerhans cell，helper T cell，cytotoxic T cell，regulatory T cell and components of extracellular matrix，such as MMP，TGF-β，VEGF consist in the microenvironment of cervical cancer as well，exercising a great influence on the genesis and development of cervical cancer. By studying the microenvironment，it will help us to further understand the mechanism of development and progression of cervical cancer，which thus provides the basis for clinical diagnosis and treatment of cervical cancer. The paper reviews recent advances of tumor microenvironment in cervical cancer. Related Articles | Metrics

Select

The Progress of Autophagy Involved in Cervical Cancer ZHAO Hong-ping;WAN An;ZHOU Ying;ZHAO Wei-dong 2015, 42 (2):  154-157.  Abstract ( 1001 )   PDF (639KB) ( 5431 )   An increasing number of studies show that the change of autophagy level in normal cell have a dual role in influencing the development of tumor and the efficacy of antitumor drugs. Cervical epithelial cell autophagy activity changing impact on the occurrence and development of cervical cancer is uncertain, and the relationship between autophagy and cervical cancer chemotherapy drug research is less autophagy activity in cervical epithelial cell impacting on the occurrence and development of cervical cancer remains to be determined. In addition, there were a few researches report the relationship between autophagy and the effect of chemotherapy drugs. Reviewing the latest research reports about the effect on autophagy occurrence and development of cervical cancer and the related research of the interaction relationship between autophagy and cervical cancer chemotherapy medicine, to further understand autophagy plays an important role in the development and treatment of cervical cancer, which provide a reference direction for the new therapy of cervical cancer. Related Articles | Metrics

Select

Research Progress of the Folate Receptor Alpha in Gynecological Malignant Tumor CHEN Liang-liang;HAO Min 2015, 42 (2):  158-160.  Abstract ( 1215 )   PDF (665KB) ( 5509 )   The folate receptor（FR） is a glycosylphosphatidylinositol linked protein, including FRα, FRβ, FRγ. Its expression is low in normal tissue except for higher in human tumor cell membrane surface in the development of tumor. In recent years, studies have shown that FRα has more expression in adenocarcinoma, such as ovarian cancer, endometrial cancer, cervical adenocarcinoma, non-small-cell lung cancer and malignant mesothelioma. Researches have shown that FRα affects the occurrence and development of tumor by participating in folic acid metabolism and estrogen receptor regulation and ERK signaling pathway. FRα expression in the gynecologic tumor is still controversial, and the specific mechanism is unknown. The study of various mechanisms of FR will be helpful in the early diagnosis and treatment of gynecological tumor. Related Articles | Metrics

论著

Select

The Down-Regulation of miR-199a in Ovarian Cancer and Its Effect on Ovarian Cancer Biological Functions ZHANG Yue;WANG Luo-qiao;LIN Qi-de;ZHANG Shu 2015, 42 (2):  161-164.  Abstract ( 1024 )   PDF (760KB) ( 5407 )   Objective： To study the expression and potential function of miR-199a in ovarian cancer occurrence and progression. Methods：Quantitative reverse transcriptase PCR（qRT-PCR） was used to detect the expression of miR-199a in 20 cases of epithelial ovarian cancers, 15 cases of benign epithelial ovarian tumors, ovary normal epithelial cell （IOSE） and ovarian cancer cells. Retrovirus expression vector pMSCVpuro-miR-199a was constructed and SKOV3 cells were transfected. CCK8 and transwell methods were used to detect the ability of proliferation and metastasis in SKOV3 cells after stably transfected with pMSCVpuro-miR-199a. Results：The mRNA expression of miR-199a in epithelial ovarian cancer group was significantly lower than that of in benign ovarian tumors （P=0.001）. Compared with IOSE cells，the miR-199a expression were down-regulated in ovarian cancer cells and expecially in SKOV3 cells（P＜0.01）. The abilities of proliferation，migration and invasion in SKOV3 cells transfected with pMSCVpuro-miR-199a were significantly lower than that in pMSCVpuro-NC SKOV3 cells（P＜0.000 1）. Conclusions：Our data suggest that the expression of miR-199a was down-regulated in ovarian cancer and miR-199a might play as an anti-oncogene in ovarian cancer proliferation and metastasis. Related Articles | Metrics

Select

Analysis and Prevention Knowledge of Cervical Cancer in Parts of Popularity Status in Huanggang City ZHANG Ling;KUANG Yuan-yuan;RAO Yong-hong;NIE Shi-shu;ZHANG Yan;MEI Jin-hua;WANG Juan 2015, 42 (2):  165-168.  Abstract ( 1060 )   PDF (652KB) ( 5402 )   Objective：Investigationg of Huanggang Tuanfeng county and Xishui county rural women cervical cancer prevention and treatment knowledge popularization, dicusses the methods and measures of improve the level of the city′s cervical cancer cognitive. Methods：Through the countryside Tuanfeng county and Xishui county of Huanggang city women cervical cancer prevention knowledge questionnaire issued, statistics aware of knowledge about prevention and control, access to cervical cancer prevention and treatment knowledge and refused to take part in the cause of cervical cancer census. Results：Old age, low degree of culture, low household income, marital instability, the floating population, women with reproductive tract infection disease always without as low awareness, Tuanfeng county and Xishui county general awareness of cervical cancer prevention knowledge rate respectively is 51.4%, 35.6%. The awareness rate of Tuanfeng county is higher than Xishui county （P＜0.01）. By the hospital, community lectures, public health publicity column and brochures and doctors face-to-face education proportion of acquiring knowledge were 30.9%, 33.2%, 27.0%, respectively. No symptoms don′t want to do after check and find out the psychological burden proportion were 50.0% and 27.7% respectively. Conclusions：Should be targeted on the low awareness and further strengthen health education in remote areas, through lectures, hospitals, community public health publicity column and brochures and the doctors face-to-face education expanded publicity. Related Articles | Metrics

Select

The Prevention of Thromboembolism Gynecologic Cancer Patients during Perioperative：A Systematic Review HUANG Jing;LI Li 2015, 42 (2):  169-174.  Abstract ( 945 )   PDF (1947KB) ( 5423 )   Objective： This study was designed to systematically analyze the world′s literature on thromboembolism prophylaxis in gynecologic oncology perioperative and evaluate the efficacy and safety of prophylaxis regimen. Methods：Computerized searches electronic databases such as Pubmed，Cochrane Library，Medline，Embase and CNKI，VIP，CBM from the date of their establishment to Sep 2014. Meta-analysis was performed on the studies meeting the criterion. Results：It included 18 randomized controlled studies and 3 193 patients. Meta analysis showed that：①The analysis of heparin-versus-control revealed a significant decrease in DVT in patients receiving heparin（RR=0.59，95%CI：0.36-0.96），but not in PE（RR=4.08，95%CI：0.71-23.53）.②LMWH-versus-control also revealed a significant decrease in DVT in patients receiving LMWH（RR=0.16，95%CI：0.05-0.47）. ③In the heparin-versus-LMWH studies，there was no significant difference（RR=0.98，95%CI：0.43-2.23）. There was no significant difference in PE in patients（RR=1.70，95%CI:0.44-6.63）. ④Combination prophylaxis can be more effectively reduce the incidence of deep vein thrombosis（RR=0.15，95%CI：0.04-0.68）. Conclusions：All gynecologic cancer patients should receive VTE prophylaxis. But no one prevention modality can be considered superior. Adequately powered RCTs are urgently needed to determine the optimal regimen in these high-risk patients. Related Articles | Metrics

综述

Select

Arachidonic Acid and Its Metabolites with Perimenopause ZHOU Zhi-wei;WANG Wen-juan;BAI Wen-pei;QIN Li-hua 2015, 42 (2):  177-179.  Abstract ( 1031 )   PDF (527KB) ( 5420 )   Arachidonic acid is one of the essential free fatty acids. Arachidonic acid and its products play an important role in regulating the body inflammation, blood vessels, elastic, leukocyte function, bone remodeling and platelet activation. Recent studies have found that arachidonic acid levels in the blood may change after menopause. Arachidonic acid and its product are related with postmenopausal hypertension, obesity, osteoporosis, etc. Moreover, after menopause, dietary factors can regulate the content of blood arachidonic acid. In this paper, before and after menopausal transition to the variation in content of arachidonic acid and its possible mechanism and postmenopausal women the relationship between diet and arachidonic acid in the body change were summarized. Related Articles | Metrics

Select

Research Progress of Estrogen Upregulation of SIRT1 Activity in Anti-aging ZHANG Hong-yan;CEN Jia-ping;LIU Yuan-wei;DENG Miao;ZHANG Zhi-fen 2015, 42 (2):  180-182.  Abstract ( 1115 )   PDF (403KB) ( 5496 )   The silent information regulator 2 (Sir2) and family proteins are highly conserved NAD+(nicotinamide adenine dinucleotide)-dependent deacetylases, and were originally discovered in yeast. SIRT1 is the highest homology with Sir2 in mammal, is considered to be long-lived protein limited by energy to give play to the role of anti-aging. SIRT1 regulates physiological processes through histones and non-histone proteins to extend life span, such as adjusting the energy metabolism, lipid oxidation and delay the onset of old age diseases such as cardiovascular development, and anti-aging. Studies have shown that estrogen plays a vital role in anti-aging. Conventional viewpoints suggested that estrogen combined with the estrogen receptor (ER) in directly or indirectly to activate the target genes in anti-aging. However, recent research shows that estrogen up-regulated SIRT1 by multiple pathways and delayed cell senescence. This paper discuss the anti-aging mechanism of estrogen by summarizing the expression pathways of estrogen up-regulating SIRT1. Related Articles | Metrics

Select

Research Progress on Construction of Endometriosis Model with Fluorescent Transfection Method SUN Mei-xing;TANG Ning-ning;WANG Ning-ning 2015, 42 (2):  183-186.  Abstract ( 980 )   PDF (633KB) ( 5410 )   Research progress of the etiological and therapeutic mechanisms of endometriosis (EMs) are still not very clear. Well established animal model which created an appropriate method of evaluation is crucial to study the etiology and experiment treatment effect of EMs. In recent years, building simple non-invasive models with fluorescent transfection method has become a new direction to establish EMs model. Considering internationally on this method with its gradual progress of establishment in vitro and in vivo, selecting transfection process, fluorescent materials and color, quantitative and dynamic observation and measurement instrument in these years, it will be useful for the summary on these aspects of the work in the EMs animal models. Related Articles | Metrics

论著

Select

Effect of Estrogen on Telomerase Activity in Ovariectomized Rats CEN Jia-ping;ZHANG Hong-yan;HUANG Jian;LIU Yuan-wei;DENG Miao;ZHANG Zhi-fen 2015, 42 (2):  187-190.  Abstract ( 982 )   PDF (756KB) ( 5391 )   Objective：The aim of this study was to investigate the anti-aging effect of oral estrogen on the telomerase activity in ovariectomized female Sprague-Dawleｙ（ＳＤ） ｒａｔｓ． Ｍｅｔｈｏｄｓ：Ｔｈｉｒｔｙ－ｔｈｒｅｅ ｔｈｒｅｅ－ｍｏｎｔｈ－ｏｌｄ ｆｅｍａｌｅ ｒａｔｓ ｗｅｒｅ ｒａｎｄｏｍｌｙ ｄｉｖｉｄｅｄ ｉｎｔｏ ｏｖａｒｉｅｃｔｏｍｉｚｅｄ ｅｘｐｅｒｉｍｅｎｔａｌ ｇｒｏｕｐ （Ｔｒｅａｔｅｄ， ｎ＝１１）， ｏｖａｒｉｅｃｔｏｍｉｚｅｄ ｃｏｎｔｒｏｌ ｇｒｏｕｐ （ＯＶＸ， ｎ＝１１） ａｎｄ ｓｈａｍ－ｏｐｅｒａｔｅｄ ｇｒｏｕｐ（Ｓｈａｍ， ｎ＝１１）． Ｔｈｅ ｒａｔｓ ｉｎ ｔｈｅ Ｔreaｔｅｄ ｇｒｏｕｐ ｗｅｒｅ ｇｉｖｅｎ ０．２１ ｍｇ/ｋｇ ｅｓｔｒａｄｉｏｌ（Ｅ２） ｖａｌｅｒａｔｅ ｉｎｔｒａｇａｓｔｒｉｃ ａｄｍｉｎｉｓｔｒａｔｉｏｎ ｗｈｉｌｅ ｏｔｈｅｒ ｔｗｏ ｇｒｏｕｐｓ ｗｅｒｅ ｇｉｖｅｎ ｔｈｅ ｅｑｕａｌ ｐｈｙｓｉｏｌｏｇｉｃａｌ ｓａｌｉｎｅ ｉｎｔｒａｇａｓｔｒｉｃ ａｄｍｉｎｉｓｔｒａｔｉｏｎ． Ａｌｌ ｏｆ ｔｈｅ ａｎｉｍａｌｓ ｗｅｒｅ ｅｕｔｈａｎｉｚｅｄ １２ ｗｅｅｋｓ ａｆｔｅｒ ｔｒｅａｔｍｅｎｔ， ａｎｄ ａｂｄｏｍｉｎａｌ ａｏｒｔｉｃ ｂｌｏｏｄ ｓａｍｐｌｅｓ ｗｅｒｅ ｔａｋｅｎ ｔｏ ａｓｓｅｓｓ ｔｈｅ ｌｅｖｅｌ ｏｆ Ｅ２， ｆｏｌｌｉｃｌｅ ｓｔｉｍｕｌａｔｉｎｇ ｈｏｒｍｏｎｅ （ＦＳＨ） ｂｙ ＥＬＩＳＡ． Ｔｅｌｏｍｅｒａｓｅ ａｃｔｉｖｉｔｙ ａｎｄ ｔｅｌｏｍｅｒａｓｅ ｒｅｖｅｒｓｅ ｔｒａｎｓｃｒｉｐｔａｓｅ（ＴＥＲＴ） ｍＲＮＡ ｅｘｐｒｅｓｓｉｏｎ ｉｎ ｔｈｅ ｈｅａｒｔ， ｌｉｖｅｒ， ｂｒａｉｎ ｔｉｓｓｕｅｓ ｏｆ ａｌｌ ｒａｔｓ ｗｅｒｅ ｍｅａｓｕｒｅｄ ｂｙ ＴＲＡＰ－ＥＬＩＳＡ ａｎｄ ＲＴ－ＰＣＲ， ｒｅｓｐｅｃｔｉｖｅｌｙ． Ｒｅｓｕｌｔｓ：Ｔｈｅ ｓｅｒｕｍ Ｅ２ ｌｅｖｅｌ ｉｎ ｔｈｅ Ｔreaｔｅｄ ａｎｄ Ｓｈａｍ ｇｒｏｕｐ ｗｅｒｅ ｓｉｇｎｉｆｉｃａｎｔｌｙ ｈｉｇｈｅｒ ｔｈａｎ ｔｈａｔ ｉｎ ｔｈｅ ＯＶＸ ｇｒｏｕｐ（Ｐ＜０．０５）． Ｔｈｅ ｓｅｒｕｍ ＦＳＨ ｌｅｖｅｌｓ ｗｅｒｅ ｓｉｇｎｉｆｉｃａｎｔｌｙ ｌｏｗｅｒ ｔｈａｎ ｔｈａｔ ｉｎ ｔｈｅ ＯＶＸ ｇｒｏｕｐ （Ｐ＜０．０５）． Ｃｏｍｐａｒｅｄ ｔｏ ｔｈｅ ＯＶＸ ａｎｄ ｔｈｅ Ｓｈａｍ ｇｒｏｕｐ， ｔｈｅ ｖａｌｕｅ ｏｆ ΔＡ ｏｎ ｔｅｌｏｍｅｒａｓｅ ａｃｔｉｖｉｔｙ ｉｎ ｔｈｅ Ｔｒｅａｔｅｄ ｇｒｏｕｐ ｗａｓ ｓｉｇｎｉｆｉｃａｎｔｌｙ ｉｎｃｒｅａｓｅｄ（Ｐ＜０．０５）． Ｔｈｅ ｔｅｌｏｍｅｒａｓｅ ａｃｔｉｖｉｔｙ ｗａｓ ｎｅｇａｔｉｖｅ ａｎｄ ΔＡ ｖａｌｕｅ ｗａｓ ｌｏｗ ｉｎ ｔｈｅ ＯＶＸ ａｎｄ Ｓｈａｍ ｇｒｏｕｐ， ｎｏ ｓｔａｔｉｓｔｉｃａｌ ｄｉｆｆｅｒｅｎｃｅ ｂｅｔｗｅｅｎ ｔｈｅｍ（Ｐ＞０．０５）． Ｔｈｅ ｖａｌｕｅ ｏｆ ＴＥＲＴ ｍＲＮＡ ΔＣｔ ｉｎ ｔｈｅ ｈｅａｒｔ， ｌｉｖｅｒ ａｎｄ ｂｒａｉｎ ｔｉｓｓｕｅｓ ｉｎ ｔｈｅ Ｔreaｔｅｄ ｇｒｏｕｐ ｗｅｒｅ ｓｉｇｎｉｆｉｃａｎｔｌｙ ｌｏｗｅｒ ｔｈａｎ ｔｈｏｓｅ ｉｎ ｔｈｅ ＯＶＸ ａｎｄ Ｓｈａｍ ｇｒｏｕｐ（Ｐ＜０．０５）． Ｂｕｔ ｔｈｅｒｅ ｗａｓ ｎｏ ｓｉｇｎｉｆｉｃａｎｔ ｄｉｆｆｅｒｅｎｃｅ ｂｅｔｗｅｅｎ ｔｈｅ ＯＶＸ ａｎｄ Ｓｈａｍ ｇｒｏｕｐ（Ｐ＞０．０５）． Ｃｏｎｃｌｕｓｉｏｎｓ：Ｅｓｔｒｏｇｅｎ ｃａｎ ｓｉｇｎｉｆｉｃａｎｔｌｙ ｕp-regulate telomerase activity and TERT mRNA expression in the ovariectomized female SD rats to delay senescence. Related Articles | Metrics

Select

The Relationship between Age, Menopausal Status and Homocysteine Level CHEN Ying 2015, 42 (2):  191-193.  Abstract ( 1214 )   PDF (522KB) ( 5376 )   Objective： To investigate the relationship between age, menopausal status and homocysteine levels. Methods：We collected 450 patients from Beijing Friendshiｐ Ｈｏｓｐｉｔａｌ ｇｙｎｅｃｏｌｏｇｉｃａｌ ｃｌｉｎｉｃ （１２３ ｐａｔｉｅｎｔｓ ｗｅｒｅ ｉｎ ｍｅｎｏｐａｕｓａｌ ｔｒａｎｓｉｔｉｏｎ ｐｅｒｉｏｄ ａｎｄ ３２７ ｐａｔｉｅｎｔｓ ｗｅｒｅ ｐｏｓｔｍｅｎｏｐａｕｓａｌ ｐｅｒｉｏｄ）． Ｐａｔｉｅｎｔｓ ａｇｅｄ ４５－６５ ｙｅａｒｓ ｏｌｄ ｎｅｖｅｒ ｕｓｅｄ ＨＲＴ ｗｅｒｅ ｍｅａｓｕｒｅｄ ｈｏｍｏｃｙｓｔｅｉｎｅ ｌｅｖｅｌｓ ｉｎ ｆａｓｔｉｎｇ ｖｅｎｏｕｓ ｂｌｏｏｄ． Ｒｅｓｕｌｔｓ：Ｏｆ ｔｈｅ ４５０ ｐａｔｉｅｎｔｓ， ｔｈｅ ｈｏｍｏｃｙｓｔｅｉｎｅ ｌｅｖｅｌ ｗａｓ ａｎ ａｖｅｒａｇｅ ｏｆ （８．４±３．１） μｍｏｌ/Ｌ， ５．７～４５．４ μｍｏｌ/Ｌ． Ｗｉｔｈｏｕｔ ｃｏｎｓｉｄｅｒｉｎｇ ｔｈｅ ｍｅｎｏｐａｕｓａｌ ｓｔａｔｕｓ ａｎｄ ｍｅｎｏｐａｕｓａｌ ｙｅａｒｓ， ｂｅｆｏｒｅ ａｎｄ ａｆｔｅｒ ｓｔｒａｔｉｆｉｃａｔｉｏｎ ｂｙ ｔｈｅ ｂｏｄｙ ｍａｓｓ ｉｎｄｅｘ， ｈｏｍｏｃｙｓｔｅｉｎｅ ｌｅｖｅｌ ｉｎ ｄｉｆｆｅｒｅｎｔ ａｇｅ ｇｒｏｕｐｓ ｓｈｏｗｅｄ ｓｉｇｎｉｆｉｃａｎｔ ｄｉｆｆｅｒｅｎｃｅｓ （Ｐ＜０．０５）． Ｗｉｔｈｏｕｔ ｃｏｎｓｉｄｅｒｉｎｇ ａｇｅ， ｔｈｅ ｈｏｍｏｃｙｓｔｅｉｎｅ ｌｅｖｅｌｓ ｗｅｒｅ ｎｏｔ ｓｉｇｎｉｆｉｃａｎｔ ｄｉｆｆｅｒｅｎｃｅｓ ｂｅｔｗｅｅｎ ｄｉｆｆｅｒｅｎｔ ｍｅｎｏｐａｕｓａｌ ｓｔａｔｕｓ ａｎｄ ｍｅｎｏｐａｕｓａｌ ｙｅａｒｓ （Ｐ＞０．０５）． Ａｆｔｅｒ ａｄｊｕｓｔｉｎｇ ｔｈｅ ａｇｅ ａｎｄ ＢＭＩ， ｔｈｅ ｈｏｍｏｃｙｓｔｅｉｎｅ ｌｅｖｅｌｓ ｗｅｒｅ ｎｏｔ ｓｉｇｎｉｆｉｃａｎｔｌｙ ｄｉｆｆｅｒｅｎｔ ｂｅｔｗｅｅｎ ｄｉｆｆｅｒｅｎｔ ｍｅｎｏｐａｕｓａｌ ｓｔａｔｕｓ ａｎｄ ｍｅｎｏｐａｕｓａｌ ｙｅａｒｓ （Ｆ＝３０．６７，Ｐ＞０．０５）． Ｃｏｎｃｌｕｓｉｏｎｓ：Ｗｉｔｈｏｕｔ ｃｏｎｓｉｄｅｒｉｎｇ ｔｈｅ ｍｅｎｏｐａｕｓａｌ ｓｔａｔｕｓ ａｎｄ ｍｅｎｏｐａｕｓａｌ ｙｅａｒｓ， ａｇｅ ｉｓ ｔｈｅ ｍａｉｎ ｆａｃｔｏｒ ａｆｆｅｃｔｉｎｇ ｈｏｍｏｃｙｓｔｅｉｎｅ ｌｅｖｅｌ ｏｆ ｗｏｍｅｎ， ｓｔｒａｔｉｆｉｃａｔｅｄ ｂｙ ｔｈｅ ｂｏｄｙ ｍａｓｓ ｉｎｄｅｘ， ａｇｅ ｓｔｉｌｌ ａｆｆｅｃｔｓ ｈｏｍｏｃｙｓｔｅｉｎｅ ｌｅｖｅｌ ｓｉｇｎｉｆｉｃａｎｔｌｙ． Ａｆｔｅｒ ａｄｊｕｓｔｉｎｇ ｔｈｅ ａｇｅ ａｎｄ ＢＭＩ， ｔｈｅ ｈｏｍｏｃｙｓｔｅｉｎｅ ｌｅｖｅｌｓ ｗｅｒｅ ｎｏｔ ｓｉｇｎｉｆｉｃａｎｔ ｄｉｆｆｅｒｅｎｔ ｂｅｔｗｅｅｎ ｄｉｆｆｅｒｅｎｔ ｍｅｎｏｐａｕｓａｌ ｓｔａｔｕｓ， ｈｏｍｏｃｙｓｔｅｉｎｅ ｌｅｖｅｌ ｄｉｄ ｎｏｔ ｃｈａｎｇｅ ｗｉｔｈ ｔｈｅ ｍｅｎｏｐａｕｓａｌ ｙｅａｒｓ． Related Articles | Metrics

Select

Expression and Clinical Significance of CD147，MCT1 and MCT4 in Cervical Lesions ZHANG Bao-yue;QU Quan-xin;GU An-kang 2015, 42 (2):  194-196.  Abstract ( 1234 )   PDF (453KB) ( 5379 )   Objective： To study the expression aｎｄ ｃｌｉｎｉｃａｌ ｓｉｇｎｉｆｉｃａｎｃｅ ｏｆ ＣＤ１４７， ｍｏｎｏｃａｒｂｏｘｙｌａｔｅ ｔｒａｎｓｐｏｒｔｅｒｓ １ （ＭＣＴ１） ａｎｄ ＭＣＴ４ ｉｎ ｃｅｒｖｉｃａｌ ｌｅｓｉｏｎｓ ａｎｄ ｃｅｒｖｉｃａｌ ｃａｎｃｅｒ． Ｍｅｔｈｏｄｓ：Ｃｈｏｏｓｅ ９２ ｐａｔｉｅｎｔｓ ｗｉｔｈ ｃｅｒｖｉｃａｌ ｌｅｓｉｏｎｓ， ｉｎｃｌｕｄｉｎｇ ４３ ｃａｓｅｓ ｏｆ ｃａｒｃｉｎｏｍａ ｏｆ ｔｈｅ ｃｅｒｖｉｘ （ｃｅｒｖｉｃａｌ ｃａｎｃｅｒ ｇｒｏｕｐ）， ３４ ｃａｓｅｓ ｗｉｔｈ ＣＩＮ（ＣＩＮ ｇｒｏｕｐ， １２ ｃａｓｅｓ ｏｆ ＣＩＮⅠ， １１ ｃａｓｅｓ ｏｆ ＣＩＮⅡ，１１ ｃａｓｅｓ ｏｆ ＣＩＮⅢ）， １５ ｃａｓｅｓ ｏｆ ｎｏｒｍａｌ ｃｅｒｖｉｃａｌ ａｓ ｃｏｎｔｒｏｌｓ （ｃｏｎｔｒｏｌ ｇｒｏｕｐ）． Ｉｍｍｕｎｏｈｉｓｔｏｃｈｅｍｉｓｔｒｙ ｗａｓ ｕｓｅｄ ｔｏ ｔｅｓｔ ａｎｄ ａｎａｌｙｚｅ ｔｈｅ ｅｘｐｒｅｓｓｉｏｎ ｏｆ ＣＤ１４７， ＭＣＴ１ ａｎｄ ＭＣＴ４． Ｒｅｓｕｌｔｓ：Ｔｈｅ ｐｏｓｉｔｉｖｅ ｅｘｐｒｅｓｓｉｏｎ ｒａｔｅｓ ｏｆ ＣＤ１４７， ＭＣＴ１ ａｎｄ ＭＣＴ４ ｉｎ ｃｅｒｖｉｃａｌ ｃａｎｃｅｒ ｇｒｏｕｐ ｗａｓ ｈｉｇｈｅｒ ｔｈａｎ ｔｈａｔ ｉｎ ＣＩＮ ｇｒｏｕｐ （ａｌｌ Ｐ＜０．０５） ａｎｄ ｃｏｎｔｒｏｌ ｇｒｏｕｐ （ａｌｌ Ｐ＜０．０５）． ＣＩＮ ｇｒｏｕｐ ｗａｓ ｈｉｇｈｅｒ ｔｈａｎ ｃｏｎｔｒｏｌ ｇｒｏｕｐ（ａｌｌ Ｐ＜０．０５）， ＣＩＮⅡ－Ⅲ ｇｒｏｕｐ ｗａｓ ｈｉｇｈｅｒ ｔｈａｎ ＣＩＮⅠ ｇｒｏｕｐ （ａｌｌ Ｐ＜０．０５）． Ｉｎ ｃｅｒｖｉｃａｌ ｃａｒｃｉｎｏｍａ ｇｒｏｕｐ， ｔｈｅ ｐｏｓｉｔｉｖｅ ｅｘｐｒｅｓｓｉｏｎ ｒａｔｅｓ ｏｆ ＣＤ１４７ ａｎｄ ＭＣＴ１ ｉｎ ａｇｅ≤３５ ｙｅａｒｓ ｏｌｄ ｇｒｏｕｐ ｗａｓ ｌｏｗｅｒ ｔｈａｎ ｔｈａｔ ｉｎ ｔｈｅ ｇｒｏｕｐ ｏｆ ａｇｅ＞３５ ｙｅａｒｓ ｏｌｄ ｇｒｏｕｐ， ｔｈａｔ ｏｆ ｓｔａｇｅ Ⅰ－Ⅱ ｇｒｏｕｐ ｉｓ ｌｏｗｅｒ ｔｈａｎ ｓｔａｇｅ Ⅲ－Ⅳ， ａｎｄ ｔｈａｔ ｏｆ ｈｉｇｈ ｄｉｆｆｅｒｅｎｔｉａｔｉｏｎ ｇｒｏｕｐ ｗａｓ ｌｏｗｅｒ ｔｈａｎ ｔｈａｔ ｉｎ ｌｏｗ ｄｉｆｆｅｒｅｎｔｉａｔｉｏｎ ｇｒｏｕｐ （ａｌｌ Ｐ＜０．０５）． Ｉｎ ｃｅｒｖｉｃａｌ ｃａｒｃｉｎｏｍａ ｇｒｏｕｐ， ｔｈｅ ｐｏｓｉｔｉｖｅ ｅｘｐｒｅｓｓｉｏｎ ｒａｔｅｓ ｏｆ ＭＣＴ４ ｉｎ ａｇｅｄ≤３５ ｙｅａｒｓ ｏｌｄ ｇｒｏｕｐ ｗａｓ ｌｏｗｅｒ ｔｈａｎ ｔｈａｔ ｉｎ ｔｈｅ ｇｒｏｕｐ ｏｆ ａｇｅ＞３５ ｙｅａｒｓ ｏｌｄ ｇｒｏｕｐ， ａｎｄ ｔｈａｔ ｏｆ ｈｉｇｈ ｄｉｆｆｅｒｅｎｔｉａｔｉｏｎ ｇｒｏｕｐ ｗａｓ ｌｏｗｅｒ ｔｈａｎ ｔｈａｔ ｉｎ ｌｏｗ ｄｉｆｆｅｒｅｎｔｉａｔｉｏｎ ｇｒｏｕｐ （ａｌｌ Ｐ＜０．０５）． Ｄｉｆｆｅｒｅｎｃｅｓ ｂｅｔｗｅｅｎ ｓｔａｇｅ Ⅰ－Ⅱ ｇｒｏｕｐ ａｎｄ ｓｔａｇｅ Ⅲ－Ⅳ ｇｒｏｕｐ ｈａｄ ｎｏ ｓｔａｔｉｓｔｉｃａｌ ｓｉｇｎｉｆｉｃａｎｃｅ． Ｔｈｅｒｅ ｗａｓ ｓｔａｔｉｓｔｉｃａｌｌｙ ｓｉｇｎｉｆｉｃａｎｔ ｃｏｎｓｉｓｔｅｎｃｙ ｂｅｔｗｅｅｎ ｔｈｅ ｅｘｐｒｅｓｓｉｏｎ ｏｆ ＭＣＴ１ ａｎｄ ＣＤ１４７ （ｗｅｉｇｈｔｅｄ Ｋａｐｐａ＝０．７７４，Z＝１０．１２６，Ｐ＜０．００１）． Ｔｈｅｒｅ ｗａｓ ｓｔａｔｉｓｔｉｃａｌｌｙ ｓｉｇｎｉｆｉｃａｎｔ ｃｏｎｓｉｓｔｅｎｃｙ ｂｅｔｗｅｅｎ ＭＣＴ４ ａｎｄ ＣＤ１４７ （ｗｅｉｇｈｔｅｄ Ｋａｐｐａ＝０．９０９，Z＝１１．６２８，Ｐ＜０．００１）． Ｔｈｅｒｅ ｗａｓ ｓｔａｔｉｓｔｉｃａｌｌｙ ｓｉｇｎｉｆｉｃａｎｔ ｃｏｎｓｉｓｔｅｎｃｙ ｂｅｔｗｅｅｎ ＭＣＴ１ ａｎｄ ＭＣＴ１ （ｗｅｉｇｈｔｅｄ Ｋａｐｐａ＝０．７９７，Z＝１０．３８３，Ｐ＜０．００１）． Ｃｏｎｃｌｕｓｉｏｎｓ：Ｔｈｅ ｅｘｐｒｅｓｓｉｏｎ ｏｆ ＣＤ１４７， ＭＣＴ１， ＭＣＴ４ ｗｅｒｅ ｃｏｎｓｉｓｔｅｎｔｌｙ ｈｉｇｈｅｒ ｌｅｖｅｌ ｉｎ ｃｅｒｖｉｃａｌ ｌｅｓｉｏｎｓ ａｎｄ ｐｌａｙ ｉｍｐｏｒｔａｎｔ ｒｏｌｅｓ ｉｎ ｔｈｅ ｄｅｖｅｌｏｐｍｅｎｔ ｏｆ ＣＩＮ ａｎｄ ｃｅｒｖｉｃａｌ ｃａｒｃｉｎｏｍａ． Ｔｈｅｙ ｃａｎ ｂｅ ａｃｃｅｐｔｅｄ ａｓ ｔｈｅ ｏｂｊｅｃｔｉｖｅｌｙ ｈｉｇｈ ｒｉｓｋ ｉｎｄｅｘｅｓ ｉｎ ｐｒｏｇｒｅｓｓｉｏｎ ｆｒｏｍ ｌｏｗ ｌｅｖｅｌ ｔｏ ｈｉｇｈ ｌｅｖｅｌ ｏｆ ＣＩＮ ａｎｄ ｃｅｒｖｉｃａｌ ｃａｎｃｅｒ． Ｌｏｗ ａｎｄ ｈｉｇｈ ｌｅｖｅｌ ＣＩＮ ｗｉｔｈ ｈｉｇｈ ｅｘｐｒｅｓｓｉｏｎ ｏｆ ＣＤ１４７， ＭＣＴ１ ａｎｄ ＭＣＴ４ ｓｈｏｕｌｄ ｂｅ ｇｉｖｅｎ ａｃｔｉｖｅ ｔｒｅａｔｍｅｎｔ ａｎｄ ｆｏｌｌｏｗｅｄ－ｕｐ． Related Articles | Metrics

Select

Effect and Mechanism of Pueraria in Women with Pelvic Floor Dysfunction YAN Bin;MA Jun;LIU Da-qing;YANG Rong;MA Qing-liang;WANG Yu 2015, 42 (2):  197-200.  Abstract ( 1207 )   PDF (760KB) ( 5394 )   Objective： By detecting collagenⅠ，collagenⅢ and elastin′s expression in pelvic ligament tissue，we can investigate the effect and possible mechanism of pueraria in women with pelvic floor dysfunction（PFD）. Methods：Select 60 menopause patients with PFD who had underwent vaginal hysterectomy from December 2010 to November 2012. Based on POP-Q score，30 patients in Ⅰ-Ⅱ degrees defined as mild group，30 patients in Ⅲ-Ⅳ degrees defined as severe group. 30 patients in the treatment group took pueraria in 60 days before the surgery including the 15 patients in Ⅰ-Ⅱ degrees and the rest in Ⅲ-Ⅳ degrees. The control group including 30 patients，15 cases in Ⅰ-Ⅱ degrees and 15 cases in Ⅲ-Ⅳ degrees，did not take any exogenous estrogen. We use HE staining to observe the form of collagen and Weigert staining to observe those of elastin. Then we use the immunohistochemical two-step method and image analysis to investigate the expression of collagen Ⅰ，collagen Ⅲ and elastin in uterosacral ligament tissue. Results：①Collagen and elastin are both widely expressed in uterosacral ligament tissue through HE and Weigert staining from light microscopy，and their staining expression in the treatment group are deeper and more even，the number are richer, and more intensive distribution than in the control group. ②In the control group，the expression of collagen Ⅰ，collagen Ⅲ and elastin in mild group ligament tissue are higher than those in the severe group（P＜0.01）. ③In the treatment group，the expression of collagen Ⅰ，collagen Ⅲ and elastin in mild or severe group ligament tissue are higher than those in the control group（P＜0.01）. Conclusions： The pueraria can increase the expression of collagen Ⅰ，collagen Ⅲ and elastin in the pelvic tissue，thereby enhancing the supportive effect of pelvic floor tissue which can relieve the symptoms of PFD. Puerarin as an effective drug for the treatment of PFD provides a possible theoretical basis. Related Articles | Metrics

Select

Explore the Relationship between Endometrial Polyp Characteristics and Abnormal Uterine Bleeding and the Influence to Its Malignancy HU Xiao-mei;GUAN Zheng;ZHOU Li;LI Jie;FAN Jun-zhen 2015, 42 (2):  201-203.  Abstract ( 1179 )   PDF (466KB) ( 5418 )   Objective： To evaluate the relationship between endometrial polyｐ（ＥＰ） ｃｈａｒａｃｔｅｒｉｓｔｉｃｓ ａｎｄ ａｂｎｏｒｍａｌ ｕｔｅｒｉｎｅ ｂｌｅｅｄｉｎｇ， ａｎｄ ａｎａｌｙｚｅ ｔｈｅ ｉｎｆｌｕｅｎｃｅ ｔｏ ｉｔｓ ｍａｌｉｇｎａｎｃｙ． Ｍｅｔｈｏｄｓ：Ｒｅｔｒｏｓｐｅｃｔｉｖｅｌｙ ｃｏｌｌｅｃｔ ｃａｓｅｓ ｆｒｏｍ Ｊａｎｕａｒｙ ２０１０ ｔｏ Ｊｕｎｅ ２０１３ ｗｈｏ ｒｅｃｅｉｖｅｄ ｈｙｓｔｅｒｏｓｃｏｐｙ ａｎｄ ｃｏｎｆｉｒｍｅｄ ｄｉａｇｎｏｓｉｓ ａｓ ｅｎｄｏｍｅｔｒｉａｌ ｐｏｌｙｐｓ ｉｎ ｏｕｒ ｈｏｓｐｉｔａｌ． Ｒｅｖｉｅｗ ａｎｄ ｓｕｍｍａｒｉｚｅ ｐｏｌｙｐ ｎｕｍｂｅｒ ａｎｄ ｓｉｚｅ ｏｆ ｅａｃｈ ｃａｓｅ， ａｎｄ ａｎａｌｙｚｅ ｔｈｅ ｒｅｌａｔｉｏｎｓｈｉｐ ｂｅｔｗｅｅｎ ｔｈｅｍ ａｎｄ ａｂｎｏｒｍａｌ ｕｔｅｒｉｎｅ ｂｌｅｅｄｉｎｇ． Ｂｙ ｐａｔｈｏｌｏｇｙ ｒｅｓｕｌｔｓ， ｔｈｅ ｐｏｌｙｐ ｐａｔｉｅｎｔｓ ｗｅｒｅ ｄｉｖｉｄｅｄ ｉｎｔｏ ｂｅｎｉｇｎ ｐｏｌｙｐ ａｎｄ ｐｏｔｅｎｔｉａｌｌｙ ｍａｌｉｇｎａｎｔ ｏｒ ｍａｌｉｇｎａｎｔ ｐｏｌｙｐｓ． Ａｎａｌｙｚｅ ｔｈｅ ｒｅｌａｔｉｏｎｓｈｉｐ ｂｅｔｗｅｅｎ ｔｈｅ ｖａｒｉｏｕｓ ｒｉｓｋ ｆａｃｔｏｒｓ ａｓｓｏｃｉａｔｅｄ ｗｉｔｈ ｍａｌｉｇｎａｎｔ ｐｏｌｙｐｓ ａｎｄ ｍａｌｉｇｎａｎｔ ｐｏｔｅｎｔｉａｌ． Ｒｅｓｕｌｔｓ：Ｏｆ ｔｈｅ ｉｎｃｌｕｄｅｄ 754 cases， 38.59%（291/754） of ｐａｔｉｅｎｔｓ with ｂｌｅｅｄｉｎｇ ｓｙｍｐｔｏｍｓ. Probability of multiple polyps and solitary polyp with bleeding were 44.26%（135/305） and 34.74%（156/449）, and the difference was statistically significant（χ2=6.94，P＜0.01）. In 449 patients with solitary polyp, probability of large（size＞10 mm） and small polyp（size ＜10 mm） with bleeding were 38.69%（106/274） and 28.57%（50/175）， and the differene was statistically significant（χ2=4.82，P＜0.05）． Ａｍｏｎｇ ｐｏｌｙｐ ｐａｔｉｅｎｔｓ， ２．９２％（22/754） ｏｆ ｐｒｅｃａｎｃｅｒｏｕｓ ｌｅｓｉｏｎｓ， ３．１８％（24/754） of ｃａｎｃｅｒｏｕｓ． Ｂｙ Ｌｏｇｉｓｔｉｃ ａｎａｌｙｓｉｓ， ｔｈｅ ｆａｃｔｏｒｓ ｏｆ ｐｏｓｔｍｅｎｏｐａｕｓｅ， ｐｏｌｙｐｓ ｄｉａｍｅｔｅｒ＞１０ ｍｍ， ｍｕｌｔｉｐｌｅ ｐｏｌｙｐｓ ａｎｄ ｍｅｒｇｉｎｇ ｂｌｅｅｄｉｎｇ ｓｙｍｐｔｏｍｓ ｈａｖｅ ａ ｓｉｇｎｉｆｉｃａｎｔ ｉｎｆｌｕｅｎｃｅ ｏｎ ｐｒｅｃａｎｃｅｒｏｕｓ ａｎｄ ｃａｎｃｅｒｏｕｓ ｐｏｌｙｐｓ（Ｐ＜０．０１）． Ｃｏｎｃｌｕｓｉｏｎｓ：Ｂｉｇｇｅｒ（＞１０ ｍｍ） ｏｒ ｍｕｌｔｉｐｌｅ ｐｏｌｙｐｓ ｍａｙ ｂｅ ｔｈｅ ｒｉｓｋ ｆａｃｔｏｒｓ ａｎｄ ｈａｖｅ ａ ｈｉｇｈｅｒ ｐｒｏｂａｂｉｌｉｔｙ ｏｆ ａｂｎｏｒｍａｌ ｕｔｅｒｉｎｅ ｂｌｅeding manifestations. Menopause，polyp diameter＞10 mm, multiple polyps, abnormal uterine bleeding are risk factors for malignant polyps. Related Articles | Metrics

Select

Clinical Study of Patients with RVVC and Intestinal Candida Yeast Infection XIA Yan;LU Qin;CHEN Mei-xin;JIN Zhi-jun 2015, 42 (2):  204-206.  Abstract ( 1121 )   PDF (475KB) ( 5422 )   Objective： Further study to the clinical study on the treatment of recurrent candida vulvovaginitis and intestinal homologous candida infection. Methods：Collect and identify vulva vaginal secretion and anal swab strains of recurrent candida vulvovaginitis patients in June 2009 to March 2013 in obstetrics and gynecology clinic, for double-positive patients, determine the homology of candida mycoderma bacteria got by separating secretion and anal swab strains by the method of PCR, divide the patients into two types of homologous patients and non homologous patients. Two types were respectively assigned to four groups randomly. Group A （ｈｏｍｏｌｏｇｏｕｓ ｓｙｓｔｅｍｉｃ ｔｒｅａｔｍｅｎｔ ｇｒｏｕｐ） ａｎｄ ｇｒｏｕｐ Ｂ （ｎｏｎ ｈｏｍｏｌｏｇｏｕｓ ｓｙｓｔｅｍｉｃ ｔｒｅａｔｍｅｎｔ ｇｒｏｕｐ） ｗｅｒｅ ｔｒｅａｔｅｄ ｗｉｔｈ ｏｒａｌ fluｃｏｎａｚｏｌｅ， ｇｒｏｕｐ Ｃ （ｈｏｍｏｌｏｇｏｕｓ ｌｏｃａｌ ｔｒｅａｔｍｅｎｔ ｇｒｏｕｐ） ａｎｄ ｇｒｏｕｐ Ｄ （ｎｏｎ ｈｏｍｏｌｏｇｏｕｓ ｌｏｃａｌ ｔｒｅａｔｍｅｎｔ ｇｒｏｕｐ） ｗｅｒｅ ｔｒｅａｔｅｄ ｗｉｔｈ ｅｘｔｅｒｎａｌ ｕｓｉｎｇ Ｍｉｃｏｎａｚｏｌｅ Ｎｉｔｒａｔｅ Ｓｕｐｐｏｓｉｔｏｒｉｅｓ ａｔ ｌｅａｓｔ ６ ｍｏｎｔｈｓ． And the patients of group A and B should be consolidation therapy at least 6 months. Ｆｏｌｌｏｗ ｕｐ １ ｙｅａｒ ａｆｔｅｒ ｆｏｕｒ ｇｒｏｕｐｓ ｐａｔｉｅｎｔｓ ｒｅｃｏｖｅｒｅｄ （Ｃｕｒａｔｉｖｅ ｅｆｆｅｃｔ ｅｖａｌｕａｔｉｏｎ ｉｎ ｔｈｅ ｒｅｓｕｌｔ ｏｆ ｃａｎｄｉｄａ ｍｉｃｒｏｓｃｏｐｉｃ ｅｘａｍｉｎａｔｉｏｎ ａｎｄ ｃｕｌｔｕｒｅ ｗｅｒｅ ｎｅｇａｔｉｖｅ）， ｔｏ ｏｂｓｅｒｖｅ ｔｈｅ ｒｅｌａｐｓｅ ｏｆ ｆｏｕｒ ｇｒｏｕｐｓ ｐａｔｉｅｎｔｓ． Ｒｅｓｕｌｔｓ：Ｔｏｔａｌ １60 ｐａｔｉｅｎｔｓ ｗｅｒｅ ｅｎｒｏｌｌｅｄ ｉｎ ＲＶＶＣ ｐａｔｉｅｎｔｓ， ｃｏｖｅｒｅｄ １１0 ｃａｓｅｓ ｏｆ ＲＶＶＣ ｈｏｍｏｌｏｇｙ ｐａｔｉｅｎｔｓ ａｎｄ ５0 ｃａｓｅｓ ｏｆ ｐａｔｉｅｎｔｓ ｗｉｔｈ ｎｏｎ ｈｏｍｏｌｏｇｏｕｓ． Ｆｏｌｌｏｗ ｕｐ ｔｈｅ ｔｒｅａｔｍｅｎｔ ｅｆｆｅｃｔ， ｇｒｏｕｐ Ａ ｓｈｏｗｅｄ ｔｈａｔ ｔｈｅ ｒｅｃｕｒｒｅｎｃｅ ｒａｔｅ ｏｆ ｔｈｅ ｐａｔｉｅｎｔｓ ｗｉｔｈ ａ ｍｉｎｉｍｕｍ ｏｆ １０．７％， ｒｅｃｕｒｒｅｎｃｅ ｒａｔｅ ｏｆ Ｃ， Ｄ ａｒｅ ｈｉｇｈ ｗｉｔｈ ７０．４％ ａｎｄ ６9．2％． Ｉｎ ｔｈｅ ｆａｃｔ ｏｆ ｆｉｒｓｔ ｔｉｍｅ ｔｏ ｒｅｌａｐｓｅ ａｎｄ ｒｅｃｕｒｒｅｎｃｅ ｄｅｇｒｅｅ， ｇｒｏｕｐ Ａ ｉｓ ｂｅｔｔｅｒ ｔｈａｎ ｔｈｅ ｏｔｈｅｒ ｔｈｒｅｅ ｇｒｏｕｐｓ， ｗｈｉｌｅ ｇｒｏｕｐ Ｃ ａｎｄ Ｄ ａｒｅ ｒｅｌａｔｉｖｅｌｙ ｗｏｒｓｅ． Ｉｎ ａｄｄｉｔｉｏｎ， ｈｏｍｏｌｏｇｙ ｔｅｓｔ ｏｆ ｄｏｕｂｌｅ ｐｏｓｉｔｉｖｅ ａｎｄ ｐａｒｔ ｏｆ ｄｏｕｂｌｅ ｐｏｓｉｔｉｖｅ ｐａｔｉｅｎｔｓ ｗｉｔｈ ｒｅｃｕｒｒｅｎｔ ｓｈｏｗｅｄ ｔｈａｔ ｔｈｅ ｅｆｆｅｃｔ ｏｆ ｓｙｓｔｅｍｉｃ ｔｒｅａｔｍｅｎｔ ｉｓ ｂｅｔｔｅｒ ｔｈａｎ ｌｏｃａｌ ｔｒｅａｔｍｅｎｔ． Ｃｏｎｃｌｕｓｉｏｎｓ：Ｆｕｒｔｈｅｒ ｃｏｎｆｉｒｍｅｄ ｔｈａｔ ｓｔｒａｉｎｓ ｔｒａｎｓｉｔｉｏｎ ｂｅｔｗｅｅｎ ｒｅｃｕｒｒｅｎｔ ｃａｎｄｉｄａ ｖｕｌｖｏｖａｇｉｎｉｔｉｓ ａｎｄ ｉｎｔｅｓｔｉｎａｌ ｈｏｍologous candida infection probably has the close relationship with the reason why part of RVVC patients last long illness. Related Articles | Metrics

Select

Exploration of the Relationship between Thyroid Dysfunction and Missed Abortion ZHANG Li-yan;ZHOU Xiao;LIU Ai-hong 2015, 42 (2):  207-208.  Abstract ( 1072 )   PDF (332KB) ( 5387 )   Objective： To investigate the correlation between thyroid dysfunction and missed abortion. Methods：We choosed 95 patients diagnosed missed abortion whose gestational age less than 12 weeks as observation group, while 92 patients who have normal pregnancy as control group. Chemiluｍｉｎｅｓｃｅｎｃｅ ｍｅｔｈｏｄ ｗａｓ ｕｓｅｄ ｔｏ ｄｅｔｅｃｔ ｔｈｅ ｓｅｒｕｍ ｌｅｖｅｌｓ ｏｆ ｔｈｙｒｏｔｒｏｐｉｎ ｈｏｒｍｏｎｅ （ＴＳＨ）， ｆｒｅｅ ｔｈｙｒｏｘｉｎｅ（ＦＴ４） ａｎｄ ｔｈｙｒｏｉｄ ｐｅｒｏｘｉｄａｓｅ ａｎｔｉｂｏｄｙ（ＴＰＯＡｂ） ｉｎ ｔｈｅ ｔｗｏ ｇｒｏｕｐｓ． Ｒｅｓｕｌｔｓ：Ｃｏｍｐａｒｉｎｇ ｔｈｅ ｉｎｃｉｄｅｎｃｅ ｏｆ ｈｙｐｅｒｔｈｙｒｏｉｄｉｓｍ， ｈｙｐｏｔｈｙｒｏｉｄｉｓｍ ａｎｄ ｌｏｗ ｔｈｙｒｏｘｉｎｅ ｉｎ ｂｏｔｈ ｇｒｏｕｐ， ｔｈｅ ｄｉｆｆｅｒｅｎｃｅ ｗａｓ ｎｏｔ ｓｔａｔｉｓｔｉｃａｌｌｙ ｓｉｇｎｉｆｉｃａｎｔ （Ｐ＞０．０５）． There were statistical differences of subclinical hypothyroidism and positive TPOAb incidence rate between observation group and control group（Ｐ＜０．０５）， and they have ｗｅａｋ ｃｏｒｒｅｌａｔｉｏｎs ｗｉｔｈ ｍｉｓｓｅｄ ａｂｏｒｔｉｏｎ （ｃｏｒｒｅｌａｔｉｏｎ ｃｏｅｆｆｉｃｉｅｎｔｓ ｗｅｒｅ ０．２１ ａｎｄ ０．２２）． Ｃｏｎｃｌｕｓｉｏｎｓ：Ｔｈｅｒｅ ｉｓ ｃｏｒｒｅｌａｔｉｏｎ ｂｅｔｗｅｅｎ ｔｈｙｒｏｉｄ ｄｙｓｆｕｎｃｔｉｏｎ ａｎｄ ｍｉｓｓｅｄ ａｂｏｒｔｉｏｎ， ｔｈｅ ｉｎｃｉｄｅｎｃｅ ｏｆ ｍｉｓｓｅｄ ａｂｏｒｔｉｏｎ ｉｓ ｉｎｃｒｅａｓｅd ｉｎ ｓｕｂｃｌｉｎｉｃａｌ ｈｙｐｏｔｈｙｒｏｉｄｉｓｍ ａｎｄ ｐｏｓｉｔｉｖｅ ＴＰＯＡｂ， ｓｏ ｗｅ ｓｈｏｕｌｄ ｃａｒｒｙ ｏｕｔ ｔｈｅ ｒｅｌｅｖａｎｔ ｃｈｅｃｋｓ ｔｈｙｒｏｉｄ ｆｕｎｃｔｉｏｎ ｉｎ ｐｒｅｇｎａｎｃｙ ｔｏ ｒｅｄｕｃｅ ｔｈｅ ｉｎｃｉｄｅｎｃｅ ｏｆ ｍｉｓｓｅｄ ａｂｏｒｔｉｏｎ． Related Articles | Metrics

综述

Select

Angiopoietins and Pregnancy WENG Dan;YIN Guo-wu;ZHU Xiao-ming 2015, 42 (2):  211-214.  Abstract ( 1268 )   PDF (502KB) ( 5401 )   The angiopoietins(Angs) are a novel family of newly-discovered angiogenic factors which are secreted by vascular endothelial cells, plays an important role in regulating angiogenesis, degeneration and vessel stabilization. Ang-1 and Ang-2 participate in the development of embryonic blood vessels, as well as the angiogenesis and metastasis of tumors. Embryo implantation is similar with tumor during pregnancy, therefore, Angs and the tyrosine kinase Tie-2 receptor reside in both placenta and fetus, the expression of Angs during pregnancy may represent a feature for embryo implantation, placental angiogenesis, as well as the growth of the fetus. Hence, in the process of pregnancy, if anyone link in angiogenesis barrier, will cause the failure of embryo and the occurence of pregnancy complications. Therefore, Angs for further study of the role of pregnancy, will help to gestational disease diagnosis and treatment. Related Articles | Metrics

Select

The Influence of Umbilical Cord Morphologic Abnormalities in Fetal Outcomes ZHANG Fan;SHAO Yong 2015, 42 (2):  215-219.  Abstract ( 1020 )   PDF (693KB) ( 5497 )   The umbilical cord is an important connection between the fetus and placenta tissue，is maternal and fetal material exchange link. In recent years，a large number of domestic and international studies have shown that abnormal umbilical cord morphology can cause fetal circulation problems leading to the occurrence of fetal and neonatal severe adverse outcomes，such as fetal growth restriction，fetal distress, neonatal asphyxia or death. The fatality rate of abnormal umbilical cord neonatal was 28.5% reported previously， Therefore，correct understanding of abnormal umbilical cord is very important. In this paper，the relationship between morphological abnormal umbilical cord and fetal outcome is reviewed. And abnormal umbilical cord length，umbilical cord entanglement，umbilical cord twist，umbilical cord knot，abnormal umbilical cord attached，single umbilical artery，and so on, all can affect fetal and neonatal adverse outcomes. Related Articles | Metrics

论著

Select

The Effect of Recombinant IL-17 Administered in the Vaginal Vaults on Normal Pregnancy CBA/J Mice LIU Hong-jie;QU Hong-mei;MA Hong-zhong;YIN Wei-hong;YU Li-li;ZHOU Xiao-jiao;WANG Wen-juan 2015, 42 (2):  220-222.  Abstract ( 1267 )   PDF (505KB) ( 5515 )   Objective： To investigate the effect of transvaginal injected recombinant IL-17 on the pregnancy outcome in the CBA/J mice model （CBA/J×BALB/c） and its role in feto-maternal immune rejection. Methods：Six to eight-week-old female CBA/J and male BALB/c were divided into three different experimental groups. Mice of normal pregnancy（CBA/J×BALB/c） received no treatment were served as control group. 50 μL phosphate-buffered saline（PBS） or 50 μL recombinant IL-17 （rIL-17） was administered in the vaginal vaults of anesthetized pregnant CBA/J mice on Day 1 of pregnancy served as PBS group and rIL-17 group individually. The numbers of surviving and reabsorbed fetuses in each group were counted, and the expression of TGF-β and IL-10 in decidua was assessed by quantitative real-time PCR and western blotting on Day 14 of pregnancy. Ｒｅｓｕｌｔｓ：In this in vivo model of normal pregnancy, exogenous rIL-17 resulted in increased spontaneous resorption of fetuses and decreased expression of TGF-β and IL-１０ （Ｐ＜０．０５）． Ａｎｄ ｔｈｅｒｅ ｗａｓ ｎｏ ｓｔａｔｉｓｔｉｃａｌ ｄｉｆｆｅｒｅｎｃｅ ｂｅｔｗｅｅｎ ＰＢＳ ｇｒｏｕｐ ａｎｄ ｃｏｎｔｒｏｌ ｇｒｏｕｐ （Ｐ＞０．０５）． Ｃｏｎｃｌｕｓｉｏｎｓ：Intravaginal rIL-17 can induce inflammation in feto-maternal interface resulting in abortion in normal pregnant CBA/J mice model. Related Articles | Metrics

Select

B-Lynch Suture in Application of Hemorrhage in Cesarean Section Postpartum LIU Hui-na;SHI Hui-rong;ZHAO Xian-lan;ZHANG Rui-tao 2015, 42 (2):  223-225.  Abstract ( 1604 )   PDF (516KB) ( 6495 )   Objective： Discuss the effect of B-Lynch suture technique to postpartum hemorrhage on cesarean section． Methods：80 patients had been subjected to cesarean section with postpartum hemorrhage. They were selected and divided into observed group（４０ ｃａｓｅｓ） ａｎｄ ｃｏｎｔｒｏｌｌｅｄ ｇｒｏｕｐ（４０ ｃａｓｅｓ）． Ｔｈｅ ｏｂｓｅｒｖｅｄ ｇｒｏｕｐ ｗａｓ ｒｅｃｅｉｖｅｄ Ｂ－Ｌｙｎｃｈ ｓｕｔｕｒｅ ｔｅｃｈｎｉｑｕｅ， ｔｈｅ ｌａｔｔｅｒ ｗａｓ ｓｕｂｊｅｃｔｅｄ ｔｏ ｔｈｅ ｔｒａｄｉｔｉｏｎａｌ ｍｅｔｈｏｄｓ ｏｆ ｈｅｍｏｓｔａｓｉｓ． Ｂｏｔｈ ｏｆ ｅｆｆｉｃｉｅｎｃｙ， ｉｎｔｒａｏｐｅｒａｔｉｖｅ ｈｅｍｏｒｒｈａｇｅ， ｏｐｅｒａｔｉｏｎ ｔｉｍｅ， ｃｏｓｔ ｏｆ ｈｏｓｐｉｔａｌｉｚａｔｉｏｎ ｗｅｒｅ ｃｏｍｐａｒｅｄ． Ｒｅｓｕｌｔｓ：Ｃｏｍｐａｒｅｄ ｗｉｔｈ ｔｈｅ ｃｏｎｔｒｏｌ ｇｒｏｕｐ， ｔｈｅ ｏｂｓｅｒｖａｔｉｏｎ ｇｒｏｕｐ ｏｆ ｌｅｓｓ ｉｎｔｒａｏｐｅｒａｔｉｖｅ ａｎｄ ｐｏｓｔｏｐｅｒａｔｉｖｅ ｂｌｏｏｄ ｌｏｓｓ，ｓｈｏｒｔｅｒ ｈｏｓｐｉｔａｌｉｚａｔｉｏｎ ｔｉｍｅ， ｈｏｓｐｉｔａｌｉｚａｔｉｏｎ ｅｘｐｅｎｓｅｓ ｌｏｗ， ｄｉｆｆｅｒｅｎｃｅｓ ｗｅｒｅ ｓｔａｔｉｓｔｉｃａｌｌｙ ｓｉｇｎｉｆｉｃａｎｔ（Ｐ＜０．０１）． Ａｎｄ ｇｏｏｄ ｐｏｓｔｏｐｅｒａｔｉｖｅ ｒｅｃｏｖｅｒｙ， ｎｏ ｃｏｍｐｌｉcations occurred. Conclusions：B-Lynch suture is an effective method of treatment of postpartum hemorrhage in cesarean section, is worth promoting. Related Articles | Metrics

Select

Expression and Significance of miRNA-203 in Endometrial Decidualization WANG Yu;CHEN Xiu-juan;LI Guang -peng;WANG Li-yan 2015, 42 (2):  226-228.  Abstract ( 1198 )   PDF (1308KB) ( 5507 )   Objective：To detect the expression of miR-203 in endometrium and decidua， and explore its significance during decidualization of endometrium. Methods：14 secretory endometria， 16 early pregnancy deciduas and 18 spontaneous miscarriage deciduas were collected in the study. MiR-203 expression level was detected by quantitative polymerase chain reaction（qPCR）. And IGF2R was predicted as the target gene of miR-203 respectively. Furthermore，the miRNA expression of IGF2R was detected by fluorescence quantitative PCR. Results：The expression of miR-203 in secretory endometrium was higher than that in spontaneous miscarriage decidua and early pregnancy decidua （P＜0.05）. Moreover，IGF2R was increased in early pregnancy，comparing with secretory endometrium and spontaneous miscarriage decidua（P＜0.05）. Conclusions：The expression of miR-203 may be associated with decidualization by targeting IGF2R. And IGF2R might associate with early pregnancy maintenance. Related Articles | Metrics

Select

Analysis of 70 Cases with Malformations in the Fetuses of Twin Pregnancy LAI Cai-qin;WANG Chen-hong;YANG Ying;LI Yu-zhe;JU Ye-lan;CHENG Li 2015, 42 (2):  229-232.  Abstract ( 1300 )   PDF (532KB) ( 5449 )   Objective：To investigate the clinical analysis from 70 cases with malformations in the fetuses of twin pregnancy from 2011 to 2013 at Shenzhen Maternal and Child Healthcare Hospital． Methods：Describe the clinical characteristics of 70 twin pregnancies complicated with fetal malformations. According to the way of conception and the type of chorionic，these twin pregnancies were divided into natural conception and artificial insemination group, monochorionic and dichorionic group respectively, and were compared the pregnancy outcomes and the main clinical characteristics by different groups. Results：65.71% of pregnant women were equal or greater than 30 years old, and 64.29% are monochorionic twins. Ｐｒｅｇｎａｎｃｙ ｃｏｍｐｌｉｃａｔｉｏｎｓ ｗｅｒｅ ｒｅｍａｒｋａｂｌｙ ｈｉｇｈｅｒ（９１．４２％）， ｔｈｅ ｔｏｐ ｆｉｖｅ ｃｏｍｐｌｉｃａｔｉｏｎｓ ｗｅｒｅ ｐｒｅｔｅｒｍ ｌａｂｏｒ， ｗｅａｋｎｅｓｓ ｏｆ ｃｏｎｔｒａｃｔｉｏｎｓ， ｐｌａｃｅｎｔａｌ ａｂｎｏｒｍａｌｉｔｙ， ｓｅｌｅｃｔｉｖｅ ｇｒｏｗｔｈ ｒｅｓｔｒｉｃｔｉｏｎ， ｈｙｐｅｒｔｅｎｓｉｖｅ ｄｉｓｏｒｄｅｒｓ ｉｎ ｐｒｅｇｎａｎｃｙ． Ｏｎｅ ｆｅｔｕｓ ａｆｆｅｃｔｅｄ ｗａｓ ８９．３３％， ｔｈｅ ｔｏｐ ｆｉｖｅ ａｂｎｏｒｍａｌｉｔｉｅｓ ｗｅｒｅ ｃａｒｄｉｏｖａｓｃｕｌａｒ ｓｙｓｔｅｍ, musculoskeletal system, urogenital system, cleft lip and palate and nervous system. Conclusions：Twin pregnancies complicated with fetal malformations are above 30 years old, and have higher incidence of complications. One fetus affected is more common than both fetuses affected; single defect is more common than multiple defects. A single system malformation is more common than multiple system malformation. The cardiovascular system malformation is the most common malformation in twin fetuses, musculoskeletal system is the second and the urogenital system malformation ranks the third. Especially in ventricular septal defect in cardiovascular malformation. So, for over 30 years old pregnant women with twins and pregnant complications, we must strengthen antenatal fetal malformation screening, and especially should focus on screening cardiovascular system, bone of limbs, urogenital system malformation. Related Articles | Metrics

Select

Telbivudine Treatment of 134 Cases of Pregnant Women with Chronic Hepatitis B CHEN Hong;WANG Feng;CHEN Peng 2015, 42 (2):  233-235.  Abstract ( 1057 )   PDF (437KB) ( 5403 )   Objective：Study was performed on the safety and efficacy of telbivudine in blocking HBV intrauterine infection of fetus in late pregnancy. Methods：In 134 cases with chronic hepatitis B is that of women in late trimester of pregnancy of 22-32 weeks when they visited our hospital, based on the wishes of patients. 134 cases were divided into treatment group（n=86, treated with oral telbivudine antiviral therapy） and control group（n=48, given with compound glycyrrhizin tablets treatment）. After the full-term babies delivered the umbilical cord blood were taken for testing of HBsAg, within 24 h for neonatal hepatitis B vaccine injection 10 μg and hepatitis B immune globulin 200 IU, at the same time sequential administration of hepatitis B vaccine immunization. Results：Patients′ age, HBV DNA quantitative, gestational weeks and liver function indexes （ALT, AST） had no significant difference before the treatments in the two groups（P＞0.05）. After treatment, HBV DNA quantitative, liver function indexes were lower than those in the control group when the pregnancies termination（P＜0.05）. The positive rate of HBsAg in treatment group was lower than that in the control group（P＜0.05） at the birth. However, the mode of delivery in patients of the 2 groups had no effect on neonatal hepatitis B infection rate（P＞0.05）. Different mode of delivery of neonatal HBV infection had no significant difference after one year（χ2CMH=0.067 8，P=0.794 5）. Conclusions：The treatment of oral telbivudine blocking HBV intrauterine infection is safe and effective, and is worthy of further promotion. Related Articles | Metrics

标准与指南

Select

The Interpretation of 2012 ASCCP Management of Abnormal Cervical Cancer Screening Tests and Cancer Precursors（Ⅱ） WANG Rong-min;PENG Jing-jing;YOU Zhi-xue 2015, 42 (2):  238-240.  Abstract ( 1085 )   PDF (461KB) ( 5474 )   Cervical cancer with definite pathogenic factors exits longer and reversible premalignant lesions which can be intervened by medical methods to decrease the morbidity and mortality. With the development of cervical cancer screening, more and more women especially young women were found with cervical intraepithelial neoplasia（CIN）. The management and intervention of precancerous lesions is an important link to prevent invasive carcinoma. Combined with American Society for Colposcopy and Cervical Pathology（ASCCP） in 2013 promulgated "2012 Updated Consensus Guidelines for the Management of Abnormal Cervical Cancer Screening Tests and Cancer Precursors", we interpretated the management of cervical precancerous lesions. The uptated guidelines of great importance to direct the clinical practice prescribed the management of CIN and highlighted the follow-up value of co-test. Related Articles | Metrics