Abstract: Objective： To investigate the correlation between thyroid dysfunction and missed abortion. Methods：We choosed 95 patients diagnosed missed abortion whose gestational age less than 12 weeks as observation group, while 92 patients who have normal pregnancy as control group. Chemiluｍｉｎｅｓｃｅｎｃｅ ｍｅｔｈｏｄ ｗａｓ ｕｓｅｄ ｔｏ ｄｅｔｅｃｔ ｔｈｅ ｓｅｒｕｍ ｌｅｖｅｌｓ ｏｆ ｔｈｙｒｏｔｒｏｐｉｎ ｈｏｒｍｏｎｅ （ＴＳＨ）， ｆｒｅｅ ｔｈｙｒｏｘｉｎｅ（ＦＴ４） ａｎｄ ｔｈｙｒｏｉｄ ｐｅｒｏｘｉｄａｓｅ ａｎｔｉｂｏｄｙ（ＴＰＯＡｂ） ｉｎ ｔｈｅ ｔｗｏ ｇｒｏｕｐｓ． Ｒｅｓｕｌｔｓ：Ｃｏｍｐａｒｉｎｇ ｔｈｅ ｉｎｃｉｄｅｎｃｅ ｏｆ ｈｙｐｅｒｔｈｙｒｏｉｄｉｓｍ， ｈｙｐｏｔｈｙｒｏｉｄｉｓｍ ａｎｄ ｌｏｗ ｔｈｙｒｏｘｉｎｅ ｉｎ ｂｏｔｈ ｇｒｏｕｐ， ｔｈｅ ｄｉｆｆｅｒｅｎｃｅ ｗａｓ ｎｏｔ ｓｔａｔｉｓｔｉｃａｌｌｙ ｓｉｇｎｉｆｉｃａｎｔ （Ｐ＞０．０５）． There were statistical differences of subclinical hypothyroidism and positive TPOAb incidence rate between observation group and control group（Ｐ＜０．０５）， and they have ｗｅａｋ ｃｏｒｒｅｌａｔｉｏｎs ｗｉｔｈ ｍｉｓｓｅｄ ａｂｏｒｔｉｏｎ （ｃｏｒｒｅｌａｔｉｏｎ ｃｏｅｆｆｉｃｉｅｎｔｓ ｗｅｒｅ ０．２１ ａｎｄ ０．２２）． Ｃｏｎｃｌｕｓｉｏｎｓ：Ｔｈｅｒｅ ｉｓ ｃｏｒｒｅｌａｔｉｏｎ ｂｅｔｗｅｅｎ ｔｈｙｒｏｉｄ ｄｙｓｆｕｎｃｔｉｏｎ ａｎｄ ｍｉｓｓｅｄ ａｂｏｒｔｉｏｎ， ｔｈｅ ｉｎｃｉｄｅｎｃｅ ｏｆ ｍｉｓｓｅｄ ａｂｏｒｔｉｏｎ ｉｓ ｉｎｃｒｅａｓｅd ｉｎ ｓｕｂｃｌｉｎｉｃａｌ ｈｙｐｏｔｈｙｒｏｉｄｉｓｍ ａｎｄ ｐｏｓｉｔｉｖｅ ＴＰＯＡｂ， ｓｏ ｗｅ ｓｈｏｕｌｄ ｃａｒｒｙ ｏｕｔ ｔｈｅ ｒｅｌｅｖａｎｔ ｃｈｅｃｋｓ ｔｈｙｒｏｉｄ ｆｕｎｃｔｉｏｎ ｉｎ ｐｒｅｇｎａｎｃｙ ｔｏ ｒｅｄｕｃｅ ｔｈｅ ｉｎｃｉｄｅｎｃｅ ｏｆ ｍｉｓｓｅｄ ａｂｏｒｔｉｏｎ．

Key words: Abortion, missed, Thyroid gland, Hypothyroidism, Peroxidases