Abstract: Invasion and metastasis is one of the important biological features of malignant tumor, which leads to the cancer patients deaths. Tumor invasion and metastasis is a complex pathological process involving many kinds of protease which including metal matrix protease, serine protease and so on. Recently, we found a type Ⅱ transmembrane serine protease named Matriptase which can enhance the process of tumor invasion and metastasis through activating urokinase-type plasminogen activator, hepatocyte growth factor/scatter factor, protease activated receptor 2 and prostate. It was closely related to the occurrence and development of a variety of malignant tumors, such as breast cancer, esophageal cancer, prostate cancer, cervical cancer, ovarian cancer and endometrial cancer. Thus, Matriptase is expected to become a new biomarker for tumor diagnosis and a promising treatment target. Now we will discuss the correlation about Matriptase and the invasion and metastasis of endometrial cancer.

Key words: Serine endopeptidases, Endometrial neoplasms, Neoplasm metastasis