Abstract: Objective： To study the effect of Angiotensin Ⅱ inhibitors，which is angiotensin converting enzyme inhibitor（ACEI）captopril and Ang Ⅱ 1 receptor inhibitor（ARB）valsartan on Ang Ⅱ-induced cervical cancer cell line HeLa AT1R，MMP2，MMP9 protein and gene expression. Methods：Treating cervical cancer HeLa cells alone with Ang Ⅱ，or combined ACEI or ARB. The MTT cell proliferation was detected by immunofluorescence staining method to detect AT1R，MMP2，MMP9 protein levels，Real-Time RT-PCR method of detection AT1R，MMP2，MMP9 gene relative expression. Results：MTT results showed that Ang Ⅱ had no significant role in promoting cell proliferation，but the ACEI and ARB could inhibit the effect of Ang Ⅱ cervical cancer HeLa cells；immunocytochemistry and Real-Time RT-PCR results showed Ang Ⅱ could significantly increase protein and gene expression of AT1R and MMP2 and MMP9，while ACEI and ARB could inhibit the role of Ang Ⅱ. Conclusions：Ang Ⅱcould promote cervical cancer HeLa cells AT1R，MMP2，MMP9 protein and gene expression，which expression could be Ang Ⅱ inhibitors captopril and valsartan inhibited，Ang Ⅱ inhibitors may be a kind of new control of cervical cancer metastasis and prolong survival in patients with cervical cancer drug.

Key words: Uterine cervical neoplasms, Angiotensin Ⅱ, Receptor, angiotensin, type 1, Receptor, type 2, Angiotensin-converting enzyme inhibitors, Captopril