Abstract: Preeclampsia（PE） is one of the leading causes of maternal and fetal/neonatal mortality and deformity around the world. At present，there are no exact early diagnostic standard of it. Once preeclampsia is diagnosed，it has caused damage to the health of mothers and infants in different degrees. For this reason，making early diagnosis before preeclampsia clinical symptoms appearance is very necessary. The existing regular prenatal diagnosis is reliable，but it would endanger the health of mothers and infants. So，exploring a specific noninvasive fast diagnosis technology is very important and has clinical significance. Circulating cell free fetal nucleic acid， including cell free fetal DNA（cffDNA），cell free fetal mRNA （cffmRNA），and microRNA， as a novel and non-invasive biomarker，which not only can effectively predict the incidence of preeclampsia but also create new path for non-invasive prenatal diagnosis， has good prospect of development. In the recent years，many researches on the relationship between the cell free fetal nucleic acid and the preeclampsia screening have been conducted. This review will summarize the related content about the discovery，tissue origin，and detection methods of cell free fetal DNA， cell free fetal mRNA，and microRNA，and their roles in preeclampsia screening.

Key words: Pre-eclampsia, Forecasting, RNA, messenger, MicroRNAs, DNA