Abstract: Epigenetics is defined as the study of inherited changes in phenotype or gene expression caused by mechanisms other than changes in the underlying DNA sequence. During cervical carcinogenesis, cancer-associated epigenetic alterations can affect the expression of HPV oncogenes. Additionally, it can control the overexpression of oncogene and underexpression of tumor-suppressor genes. Recent researches have proved that the abnormal interaction miRNAs and epigenetics definitively linked to HPV associated cervical cancer. Aberrant epigenetics are involved in silencing of tumor-suppressor miRNAs in carcinogenesis. On the other hand, miRNAs can improve the repair of viral DNA and silence tumor-suppressor genes by regulating DNA methylation or histone modifications.

Key words: Epigenesis, genetic, MicroRNAs, Uterine cervical neoplasms, Papillomaviridae