Abstract: Perimenopause is the age of high incidence of ovarian cancer， because there are no obvious symptoms in early stage and lack of effective early diagnostic tool，mortality is the highest in the gynecological cancers. Gene chips，proteomics and immunohistochemical tecnology and other research methods have become research hotspot in early diagnosis of ovarian cancer，but there is no definite conclusion. Therefore，we need to define a new systematic， highly sensitive and specific method in early diagnosis of ovarian cancer，and screening of early ovarian cancer in the population，so that can early diagnosis and treatment，then further improve the quality of life of patients.

Key words: Ovarian neoplasms, Early diagnosis, Microchip analytical procedures, Proteomics, Tumor markers, biological