国际妇产科学杂志

国际妇产科学杂志 ›› 2021, Vol. 48 ›› Issue (6): 710-713.doi: 10.12280/gjfckx.20210113

• 普通妇科疾病及相关研究:论著 • 上一篇    下一篇

宫颈HPV感染状况及其与宫颈柱状上皮异位的相关性研究

陈秀杰#, 王嫱#, 王雅楠, 郭洁, 赵琳, 张崴, 宋殿荣()   

  1. 300250 天津中医药大学第二附属医院妇科（陈秀杰,王雅楠,郭洁,赵琳,张崴,宋殿荣）; 天津中医药大学研究生院（王嫱）
  • 收稿日期:2021-01-28 出版日期:2021-12-15 发布日期:2021-12-30
  • 通讯作者: 宋殿荣 E-mail:songdr58@126.com
  • 基金资助:
    天津市卫生健康委天津市中医药管理局中医中西医结合科研课题(2019076)

Study on the HPV Infection and Its Correlation with Cervical Columnar Ectopy

CHEN Xiu-jie#, WANG Qiang#, WANG Ya-nan, GUO Jie, ZHAO Lin, ZHANG Wei, SONG Dian-rong()   

  1. Department of Gynecology, Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China (CHEN Xiu-jie, WANG Ya-nan, GUO Jie, ZHAO Lin, ZHANG Wei, SONG Dian-rong); Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China (WANG Qiang)
  • Received:2021-01-28 Published:2021-12-15 Online:2021-12-30
  • Contact: SONG Dian-rong E-mail:songdr58@126.com

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摘要：

目的: 研究妇科门诊就诊患者宫颈人乳头瘤病毒（human papilloma virus,HPV）感染状况及其与宫颈柱状上皮异位的相关性,为HPV感染防治提供临床证据。方法: 选取2018年5月—2019年12月在天津中医药大学第二附属医院妇科门诊行宫颈HPV检测的1 130例患者为研究对象,其年龄范围为21~65岁,就诊原因主要包括生殖内分泌疾病、阴道分泌物异常、既往HPV感染、妇科肿瘤、子宫内膜异位症和妇科体检,记录妇科检查时肉眼观察下的宫颈外观,采用荧光聚合酶链反应对宫颈细胞标本进行HPV检测,分析不同年龄、就诊原因和宫颈外观者的HPV感染情况。结果: HPV的总感染率为40%（452/1 130）。前5位最常见的HPV感染型别依次是HPV16,58,52,51和18型。在就诊患者中,60~65岁年龄组HPV感染率最高,达74.07%;因阴道分泌物异常就诊患者HPV感染率最高（54.57%）,其次是因既往HPV感染者（50.77%）。宫颈光滑组及宫颈柱状上皮异位组间HPV总感染率（39.94% vs. 40.08%）、高危型HPV感染率（33.75% vs. 34.09%）、低危型HPV感染率（4.33% vs. 3.93%）、疑似高危型HPV感染率（1.86% vs. 2.07%）、单一型别HPV感染率（28.95% vs. 28.10%）和多重型别HPV感染率（10.99% vs. 11.98%）比较,差异均无统计学意义（P>0.05）。结论: HPV感染与宫颈柱状上皮异位无关,在临床工作中应加强对高龄、阴道分泌物异常及既往HPV感染患者HPV筛查,及时发现HPV持续感染,针对性地予以干预,有效预防宫颈癌及癌前病变的发生。

关键词: 人乳头状瘤病毒DNA检测, 乳头状瘤病毒科, 宫颈柱状上皮异位, 宫颈疾病, 重叠感染

Abstract:

Objective:To study the human papilloma virus (HPV) infection conditions in patients from gynecology outpatient department and its correlation with cervical columnar ectopy, to provide clinical evidence for prevention and treatment of HPV infection.Methods: Selected 1 130 patients who accepted cervical HPV screening in the gynecology outpatient department of the Second Affiliated Hospital of Tianjin University of TCM from May 2018 to December 2019 as the research subjects, age ranged from 21 to 65 years old, and the main reasons for visiting included reproductive endocrine diseases, abnormal vaginal secretions, previous HPV infection, gynecological tumors, endometriosis and gynecological physical examination, recorded the appearance of cervix simultaneously, detected HPV using fluorescent polymerase chain reaction technology, and analyzed the conditions of HPV infection and its correlation with ages, reasons for medical visits and cervical appearance.Results: The overall HPV infection rate was 40.00% (452/1 130). The top five of the most common types of HPV infection were 16, 58, 52, 51 and 18 in order. The HPV infection rate was the highest in the 60-65 years old group, accounting for 74.07%. The HPV infection rate was the highest in patients with abnormal vaginal discharge (54.57%), followed by patients with previous HPV infection (50.77%). There was no statistical difference (P>0.05) between cervical columnar ectopy group and smoothy cervix group including total HPV infection rate (39.94% vs. 40.08%), high-risk HPV(HR-HPV) infection rate (33.75% vs. 34.09%), low-risk HPV infection rate (4.33% vs. 3.93%), possible HR-HPV infection rate (1.86% vs. 2.07%), single subtype HPV infection rate (28.95% vs. 28.10%) and multiple HPV infection rate (10.99% vs. 11.98%).Conclusions: There is no relationship between HPV infection and cervical columnar ectopy. We should strengthen the HPV screening for patients with advanced age, abnormal vaginal secretions, and previous HPV infection in clinical work, detect persistent HPV infection in time, and make targeted interventions to effectively prevent cervical cancer and precancerous lesion.

Key words: Human papilloma virus DNA tests, Papillomaviridae, Cervical columnar ectopy, Uterine cervical diseases, Superinfection