维生素B12缺乏与不良妊娠结局

doi:10.12280/gjfckx.20211141

摘要/Abstract

摘要：

维生素B12是人体必需的水溶性维生素,作为甲硫氨酸合酶和甲基丙二酰辅酶A变位酶的辅酶,参与叶酸循环、甲硫氨酸循环以及DNA合成,还可降低血清同型半胱氨酸水平,在妊娠期发挥重要生理作用。由于妊娠期母体对维生素B12的需求增加,如果同时伴有摄入不足、吸收障碍或利用不良,易引起妊娠期维生素B12缺乏,可以导致妊娠期糖尿病、早产、流产、低出生体质量儿和神经管畸形等妊娠期并发症,但其致病机制尚未完全明确。综述维生素B12缺乏与不良妊娠结局的研究进展,为临床诊疗提供思路。

关键词: 维生素B12缺乏, 叶酸, 高同种半胱氨酸血症, 妊娠并发症, 妊娠结局

Abstract:

Vitamin B12 is an essential water-soluble vitamin. As a coenzyme of methionine synthase and l-methylmalonyl-CoA mutase, it participates in folic acid, methionine cycle and DNA synthesis, while it can reduce blood homocysteine concentration, which plays an important physiological role during pregnancy. Due to the increased maternal demand for vitamin B12 during pregnancy, if accompanied by insufficient intake, malabsorption or malutilization, it is easy to cause vitamin B12 deficiency during pregnancy, which can lead to gestational diabetes mellitus, premature birth, miscarriage, low birth weight, neural tube defects and other pregnancy complications, but the pathogenic mechanism is not fully understood. This article reviews the research progress of vitamin B12 deficiency and adverse pregnancy outcomes, and provides ideas for clinical diagnosis and treatment.

Key words: Vitamin B 12 deficiency, Folic acid, Hyperhomocysteinemia, Pregnancy complications, Pregnancy outcome

王天晶, 陈丹青. 维生素B12缺乏与不良妊娠结局[J]. 国际妇产科学杂志, 2022, 49(4): 420-425.

WANG Tian-jing, CHEN Dan-qing. Vitamin B12 Deficiency and Adverse Pregnancy Outcomes[J]. Journal of International Obstetrics and Gynecology, 2022, 49(4): 420-425.

图/表 1

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