国际妇产科学杂志

国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (2): 119-121.

• 综述 • 上一篇    下一篇

人乳头瘤病毒16/18型与宫颈癌

孙志辉,岳天孚   

  1. 300052 天津医科大学总医院妇产科
  • 收稿日期:2009-10-09 修回日期:1900-01-01 出版日期:2010-04-15 发布日期:2010-04-15

Human Papillomavirus Type 16/18 and Cervical Cancer

SUN Zhi-hui, YUE Tian-fu   

  1. Tianjin Medical University General Hospital, Tianjin 300052, China
  • Received:2009-10-09 Revised:1900-01-01 Published:2010-04-15 Online:2010-04-15

PDF (PC)

4955

摘要： 人乳头瘤病毒（HPV）16/18型和宫颈癌的关系密切，在宫颈癌发生发展中起重要作用。HPV16最易导致宫颈鳞癌，HPV18最易导致宫颈腺癌。HPV16/18致癌机制主
要是通过病毒基因组中致癌蛋白E6，E7与抑癌基因p53和pRb结合，E6抑制p53的活性，E7灭活Rb基因的活性，致肿瘤发生。常用的HPV检测方法有原位杂交法（ISH）、第二代杂交捕
获试验（HCⅡ）、聚合酶链反应（PCR）等。针对HPV16/18的预防和治疗性疫苗成为研究热点。综述HPV16/18型和宫颈癌关系研究进展。

关键词: 人乳头瘤病毒, 宫颈癌, 致癌机制, 检测方法, 疫苗

Abstract: Human papilloma virus （HPV） 16/18 relates closely with cervical cancer and it plays an important role in the development of cervical
cancer. Cervical squamous cell carcinoma is most easily induced by HPV16 and cervical adenocarcinoma most easily induced by HPV18. Cervical cancer is caused
by HPV 16/18 mainly through carcinogenes is protein E6 E7 of virus genome and anti-oncogene p53 PRb. p53 activity is inhibited by E6 while E7 inactivition of
Rb is inactivated by E7. The common detection method of HPV is in situ hybridization（ISH）, the
molecular hybridization capture Ⅱ（HCⅡ） and polymerase chain reaction （PCR）, etc. Study in preventive and
therapeutic HPV16/18 vaccines is a hot spot. Review on the relationship between HPV16/18 and cervical cancer.

Key words: Human papilloma virus, Cervical cancer, Cancer mechanism, Detection methods, Vaccines