国际妇产科学杂志

国际妇产科学杂志 ›› 2011, Vol. 38 ›› Issue (3): 241-244.

• 综述 • 上一篇    下一篇

血管内皮生长因子与宫颈癌转移的研究进展

彭孝莲,吴宜林   

  1. 414300 湖南省临湘市人民医院妇产科（彭孝莲）； 中南大学湘雅二医院（吴宜林）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-06-15 发布日期:2011-06-15

The Research Progress of Vascular Endothelial Growth Factor and Cervical Cancer Metastasis

PENG Xiao-lian，WU Yi-lin   

  1. Department of Obstetrics and Gynecology，the people′s Hospital of Linxiang City, Hunan Province，Linxiang 414300，China（PENG Xiao-lian）；The Second Xiangya Hospital of Central South University，Changsha 410011，China（WU Yi-lin）
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-06-15 Online:2011-06-15

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摘要： 血管内皮生长因子（VEGF）是强有力的血管生成有丝分裂原，可诱导肿瘤新生血管、淋巴管形成，与宫颈癌转移和预后密切相关。VEGF可增加血管渗透性引起血流抵抗、减少肿瘤血液供应，影响细胞毒药物的组织分布和疗效。VEGF抑制剂可诱导肿瘤血管正常化，增强药物吸收，是目前宫颈癌分子靶向治疗的研究热点

关键词: 血管内皮生长因子类, 宫颈肿瘤, 肿瘤转移, 血管生成抑制剂

Abstract: Vascular endothelial growth facto（VEGF） is a potent mitogen of angiogenesis.It can induce angiogenesis and lymphangiogenesis in tumor.Furthermore，VEGF significantly associates with lymphatic metastasis and prognosis of cervical carcinoma.VEGF causes hyperpermeable formation of vessel，leading to resistance to blood flow and impair blood supply and therefore compromise the distribution and effectiveness of conventional cytotoxic therapies.Aantagonist may induce the morphological normalization of tumor vasculature and increase drug uptake. It is currently a hot topic in molecular targeted therapies of cervical carcinoma.

Key words: Vascular endothelial growth factors, Uterine cervical neoplasms, Neoplasm metastasis, Angioge- nesis inhibitors