国际妇产科学杂志

国际妇产科学杂志 ›› 2011, Vol. 38 ›› Issue (4): 311-315.

• 综述 • 上一篇    下一篇

宫颈癌发生过程中的表观遗传异常


邢 洁 , 李 阳,吕卫国 , 谢 幸   

  1. 310006 杭州,浙江大学医学院附属妇产科医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-08-15 发布日期:2011-08-15
  • 通讯作者: 谢 幸

Epigenetic Alterations in Cervical Carcinogenesis

XING Jie, LI Yang, LU Wei-guo, XIE Xing   

  1. Women′s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-08-15 Online:2011-08-15
  • Contact: XIE Xing

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摘要： 表观遗传指DNA序列不发生变化，而基因表达却发生可遗传的改变。在宫颈癌发生过程中，表观遗传改变不仅影响着人乳头瘤病毒（HPV）致癌基因的异常表达，而且可导致宿主细胞多个癌基因激活和抑癌基因的失活。近年发现，表观遗传和微小RNA（miRNA）相互调控异常也与宫颈癌发生密切相关。表观遗传异常可导致具有抑癌作用的miRNA沉默表达，miRNA也可通过DNA甲基化和组蛋白修饰促进病毒的DNA修复、抑癌基因表达沉默。

关键词: 后成说, 遗传, 微RNAs, 宫颈肿瘤, 乳头状瘤病毒科

Abstract: Epigenetics is defined as the study of inherited changes in phenotype or gene expression caused by mechanisms other than changes in the underlying DNA sequence. During cervical carcinogenesis, cancer-associated epigenetic alterations can affect the expression of HPV oncogenes. Additionally, it can control the overexpression of oncogene and underexpression of tumor-suppressor genes. Recent researches have proved that the abnormal interaction miRNAs and epigenetics definitively linked to HPV associated cervical cancer. Aberrant epigenetics are involved in silencing of tumor-suppressor miRNAs in carcinogenesis. On the other hand, miRNAs can improve the repair of viral DNA and silence tumor-suppressor genes by regulating DNA methylation or histone modifications.

Key words: Epigenesis, genetic, MicroRNAs, Uterine cervical neoplasms, Papillomaviridae