国际妇产科学杂志

国际妇产科学杂志 ›› 2011, Vol. 38 ›› Issue (5): 398-401.

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免疫型复发性流产的发病机制与治疗

刘长明,丛 林   

  1. 230022 合肥袁安徽医科大学第一附属医院妇产科产 前诊断中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-10-15 发布日期:2011-10-15
  • 通讯作者: 丛 林

The Pathogenesis and Treatment Updates of Recurrent Spontaneous Abortion with Immune Type

LIU Chang-ming，CONG Lin   

  1. Prenatal Diagnosis Center，Department of Obstetrics and Gynecology，the First Affiliated Hospital of Anhui Medical University，Hefei 230022，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-10-15 Online:2011-10-15
  • Contact: CONG Lin

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摘要： 复发性流产（RSA）的病因复杂，目前有近50%的复发性流产发病机制尚不明确。对免疫型复发性流产的研究是近年来自然流产研究的重点。免疫型复发性流产的发生与母体系统免疫和蜕膜局部微环境免疫异常有关，其中自身免疫型复发性流产主要与抗磷脂抗体（APLA）阳性有关，而同种免疫型复发性流产则与母胎界面多种免疫细胞或细胞因子比例失调有关。针对复发性流产有多种治疗方法，但治疗效果尚无定论。

关键词: 流产, 习惯性, 自身免疫, 免疫耐受, 淋巴细胞, 细胞因子类

Abstract: The pathogenesis of recurrent spontaneous abortion（RSA）is complex，there are nearly 50% RSA for unexplained reasons. Recurrent spontaneous abortion with immune type is the focus of spontaneous abortion research in recent years. The abnormalities of maternal immune system and decidual microenvironment are correlated with RSA of immune type. The pathogenesis of autoimmune RSA was mainly associated with anti-phosphlipid antibody（APLA），while that of alloimmune RSA was due to the imbalance of multi-kinds of immune cells and cytokines. Currently there are several methods for RSA treatment；none of them was publicly established.

Key words: Abortion, habitual, Autoimmunity, Immune tolerance, Lymphocytes, Cytokines