国际妇产科学杂志

国际妇产科学杂志 ›› 2011, Vol. 38 ›› Issue (5): 432-435.

• 综述 • 上一篇    下一篇

ALA-PDT治疗子宫颈病变的研究进展


林倩如, 隋 龙   

  1. 200011 上海,复旦大学附属妇产科医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-10-15 发布日期:2011-10-15
  • 通讯作者: 隋 龙

The Update Research on Therapy of Cervical Neoplasia by 5-aminolevulinic Acid-based Photodynamic Therapy

LIN Qian-ru，SUI Long   

  1. The Gynecology and Obstetrics Hospital of Fudan University，Shanghai 200011，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-10-15 Online:2011-10-15
  • Contact: SUI Long

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摘要： 现已明确持续性的人乳头瘤病毒（HPV）感染与宫颈上皮内瘤样病变（CIN）、宫颈癌的关系密切，目前用于治疗CIN的疗法在治疗后易复发、造成组织损伤，甚至破坏宫颈结构影响生育。因此，急需一种疗效确切、不良反应低的新疗法。5-氨基酮戊酸（ALA）是第二代新型光敏剂，广泛应用于光动力治疗（PDT），ALA-PDT通过局部应用光敏剂，在光照射后产生单线态氧，从而杀伤靶细胞。目前其应用于HPV感染的CIN等病变，与传统治疗方法相比有其优越性。对ALA-PDT应用于子宫颈病变的基础及其临床治疗进行综述，为进一步深入研究提供理论依据。

关键词: 光化学疗法, 宫颈肿瘤, 宫颈上皮内瘤样病变, 人乳头瘤病毒, 5-氨基酮戊酸

Abstract: Now there is a clear close relationship between persistent human papillomavirus（HPV）infection and cervical intraepithelial neoplasia（CIN）and cervical cancer. Current therapies for the treatment of CIN may easy to recur，bring damage to normal tissue and even destroy cervix structure affecting fertility. Therefore，we urgently need a new therapy of specific effects and low side-effect. 5-aminolevulinic acid（ALA）is the second-generation of photosensitizer and widely used for photodynamic therapy（PDT）. The mechanism of ALA-PDT is that the production of singlet oxygen kills the targeted cells when ALA is topically used and irradiated. Today，ALA-PDT is applied to treat HPV-related dysplasia like CIN. Compared to traditional treatments，the application has its own superiority. This review aims to give an overview about the current applications in basic research and clinical treatment and provide a basis for further research.

Key words: Photochemotherapy, Uterine cervical neoplasms, Cervical intraepithelial neoplasia, Human papillomavirus, 5-aminolevulinic acid