国际妇产科学杂志

国际妇产科学杂志 ›› 2012, Vol. 39 ›› Issue (1): 60-63.

• 综述 • 上一篇    下一篇

子宫内膜癌中肿瘤干细胞的研究进展

郭斐斐,周怀君   

  1. 210009 南京,东南大学医学院(郭斐斐);南京市鼓楼医院妇产科(周怀君)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-02-15 发布日期:2012-02-15
  • 通讯作者: 周怀君

Research Progress on Tumor Stem Cells in Endometrial Carcinoma

GUO Fei-fei，ZHOU Huai-jun   

  1. Medical College of Southeast University，Nanjing 210009，China（GUO Fei-fei）；Department of Obstetrics and Gynecology，Nanjing Drum Tower Hospital，Nanjing 210008，China（ZHOU Huai-jun）
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-02-15 Online:2012-02-15
  • Contact: ZHOU Huai-jun

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摘要： 子宫内膜癌是妇科常见的三大恶性肿瘤之一，严重影响女性的生活和健康。现行的治疗手段主要包括手术、放射治疗（放疗）和化学治疗（化疗），但对放疗或化疗后复发病例的治疗，仍是极大的挑战。肿瘤干细胞是一类存在于肿瘤组织中具有自我更新能力和多向分化潜能的肿瘤细胞亚群，目前肿瘤干细胞的研究方兴未艾。在子宫内膜癌发病机制的研究中，大量研究证实具有干细胞潜能的稀有的子宫内膜癌肿瘤细胞在疾病发生、发展、转移和复发中起关键作用。就肿瘤干细胞的性质、来源做一总结，并对子宫内膜癌中肿瘤干细胞存在的证据及其标记物的研究进展作一综述。

关键词: 肿瘤干细胞, 肿瘤干细胞测定, 子宫内膜肿瘤, 肿瘤标记, 生物学, RNA结合蛋白质类

Abstract: Endometrial cancer is one of the most common gynaecological malignancies afflicting the lives and health of the women.Surgery，chemotherapy，and radiation protocols have been established for the treatment of endometrial cancer，however，the treatment for the recurrent patients that have acquired radio-or chemoresistance poses a major challenge for us. Tumor stem cells are defined as a subset of tumour cells with the potential to self-renew and give rise to the differentiated cells that comprise the bulk of the tumour.And the researches about tumor stem cells are just in the ascendant. Emerging evidence indicates that the rare tumor cells with the potentiality of endomrtrial cancer tumor stem cell are likely responsible for the development，progression，metastisis and recurrance of endometrial cancer in the researches about the mechanism of the endometrial cancer. This review is a conclution of the characters and sources of the tumor stem cells，and the research progress on tumor stem cells and its markers in endometrial cancer.

Key words: Neoplastic stem cells, Tumor stem cell assay, Endometrial neoplasms, Tumor markers, biological, RNA-binding proteins