国际妇产科学杂志

国际妇产科学杂志 ›› 2012, Vol. 39 ›› Issue (3): 228-230.

• 综述 • 上一篇    下一篇

Stathmin与子宫蜕膜化关系的研究进展

李 密,吴 琨, 唐 莉   

  1. 650500 昆明医学院第一附属医院妇产科(李密,吴琨);云南省第一人民医院生殖遗传一科(唐莉)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-06-15 发布日期:2012-06-15
  • 通讯作者: 唐 莉

Advanced Study of Stathmin with Decidualization

LI Mi，WU Kun，TANG Li   

  1. Department of Obstetrics and Gynecology，the First Hospital of Kunming Medical University，Kunming 650500， China（LI Mi，WU Kun）；Reproductive Genetic Division One，First People′s Hospital of Yunnan Province，Tunming 650032，China（TANG Li）
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-06-15 Online:2012-06-15
  • Contact: TANG Li

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4748

被引次数

3

摘要： Stathmin作为一种微管失稳蛋白影响了细胞周期进程，其在人类子宫内膜组织的腺上皮和基质细胞中有所表达。研究表明，stathmin在调节人子宫内膜基质细胞分化过程中的初始阶段起着必不可少的作用，和蜕膜化相关。Stathmin在子宫内膜蜕膜化、蜕膜的分化增殖与凋亡和蜕膜相关细胞的侵袭与黏附方面均起了重要作用。而蜕膜化作为正常着床和妊娠的一个重要特征，与子面滋养层共同构成母胎界面，从而影响正常早期妊娠，并可能与早期自然流产相关。

关键词: 微管蛋白质类, 癌蛋白18, 子宫内膜, 蜕膜

Abstract: Stathmin was detected expression in human endometrial epithelia and stromal cells and impacted in the progression of cell cycles as a microtuble unstable protein. It was reported that the transformation from endometrium to decidua is an important characteristics of embryo implantation. Stathmin may play a critical role in endometrial decidualization， differentiation and proliferation，apoptosis of decidual，invasion and adhesion of the decidual related cells. As an important feature of normal implantation and pregnancy， decidualization and sub-surface trophoblast constitute a maternal-fetal interface， thus affecting the normal early pregnancy， and may be related to early spontaneous abortion. This article will summarize the studies about stathmin with the decidualization.

Key words: Microtubule proteins, Stathmin, Endometrium, Decidua