国际妇产科学杂志

国际妇产科学杂志 ›› 2013, Vol. 40 ›› Issue (3): 230-233.

• 综述 • 上一篇    下一篇

微小RNA与认知功能障碍

张 敏,吴 洁   

  1. 210029 南京医科大学第一附属医院生殖医学国家重点实验室（张敏），妇产科（吴洁）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-06-15 发布日期:2013-06-15
  • 通讯作者: 吴 洁

miRNAs and Cognitive Impairment

ZHANG Min，WU Jie   

  1. State Key Laboratory of Reproductive Medicine（ZHANG Min），Department of Obstetrics and Gynecology（WU Jie），the First Affiliated Hospital of Nanjing Medical University， Nanjing210029，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-06-15 Online:2013-06-15
  • Contact: WU Jie

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摘要： 微小RNA（microRNA，miRNA）是一类长度约22个核苷酸的小分子非编码RNA，目前已成为医学和分子生物学等领域的关注热点。作为强大的转录后调控因子，miRNA通过与靶mRNA特定位点的结合来抑制蛋白质的合成，从而参与细胞分化、增殖与凋亡、激素分泌等一系列重要生命活动。近年研究表明，多种miRNA对神经系统发生和发育、神经干细胞分化、突触联系、树突棘形成和神经保护等发挥了极其重要的作用。综述miRNA在海马、认知功能障碍以及神经退行性疾病中的研究进展，旨在为绝经后妇女认知功能障碍的防治提供新的思路。

关键词: 微RNAs, 海马, 认知障碍, 神经系统疾病, 绝经期

Abstract: miRNAs are small noncoding regulatory RNAs of 22 nucleotides in length that always become and pay close attention to the focus in the field of medicine and molecular biology. miRNAs play a role at posttranscriptional level by inhibiting sequence-specific translation or degrading mRNA via binding to target genes during the hyperplasia，differentiation and death of cell as well as hormone secretion. Recently，a link between miRNAs and development of the central nervous system，such as the differentiation of neural stem cells，synaptic connections，dendritic spinesor or neuroprotective effects，is becoming increasingly clear. Therefore，the central aim of this review is to highlight recent findings in the field of miRNAs inhippocampus，and a potential interaction between microRNAs and neurodegenerative diseases including cognitive impairment and Alzheimer′s disease，that provides newideas for future prevention and treatment of diseases.

Key words: MicroRNAs, Hippicampus, Cognition disorders, Nervous system diseases, Menopause