国际妇产科学杂志

国际妇产科学杂志 ›› 2014, Vol. 41 ›› Issue (1): 25-28.

• 综述 • 上一篇    下一篇

干细胞治疗卵巢早衰的研究进展

左侠，陈蕾   

  1. 100048 北京，中国人民解放军海军总医院妇产科（左侠，陈蕾）；第四军医大学（左侠）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-02-15 发布日期:2014-02-15
  • 通讯作者: 陈蕾

Research Progress of Stem Cells in the Treatment of Premature Ovarian Failure

ZUO Xia，CHEN Lei   

  1. Department of Obstetrics and Gynecology，PLA Navy General Hospital，Beijing 100048，China（ZUO Xia，CHEN Lei）；The Fourth Military Medical University，Xi′an 710032，China（ZUO Xia）
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-02-15 Online:2014-02-15
  • Contact: CHEN Lei

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摘要： 卵巢早衰（POF）是由多种病因导致的卵泡功能衰竭。大约80%患者属于特发性POF。POF治疗棘手，近年国内外取得了应用干细胞恢复卵巢功能及生育力等方面的动物试验成果，为POF患者卵巢功能及生育功能的恢复带来了希望。干细胞包括胚胎干细胞和成体干细胞，胚胎干细胞治疗因其引起伦理争议而受到限制。目前成体干细胞治疗包括生殖干细胞、骨髓间充质干细胞和胎儿间充质干细胞的治疗。干细胞可能通过分化为卵母细胞或通过旁分泌抑制卵泡凋亡来修复受损卵巢。现对POF的干细胞治疗进展进行综述。

关键词: 卵巢功能早衰, 干细胞, 胚胎干细胞, 成体干细胞

Abstract: Premature ovarian failure（POF） refers to failure of follicle function which is caused by a variety of causes. About eighty percentages of POF belongs to idiopathic POF. Therapy of POF is very tricky. In recent years，stem cell therapy has obtained some achievements in the restoration of ovarian function in animal experiments at home and abroad. These achievements bring hope in aspect of recovery of ovarian function and fertility for patients with POF. Stem cell includes embryonic stem cells and adult stem cells. Study in embryonic stem cell therapy is restricted because of ethical controversy. The adult stem cell therapy includes germline stem cell therapy，bone marrow mesenchymal stem cell therapy，fetal mesenchymal stem cells therapy. Stem cells may differentiate into oocytes or inhibit follicle apoptosis through paracrine to restore damaged ovaries. This article mainly reviews research progress about stem cell therapy of POF.

Key words: Ovarian failure, premature, Stem cells, Embryonic stem cells, Adult stem cells