国际妇产科学杂志

国际妇产科学杂志 ›› 2014, Vol. 41 ›› Issue (4): 401-404.

• 综述 • 上一篇    下一篇

微小RNA与子宫内膜癌相关性的研究进展

刘麒薇，杨敏，童晓文，王建军   

  1. 200092 上海，同济大学医学院（刘麒薇，杨敏）；上海市同济医院妇产科（童晓文，王建军）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-08-15 发布日期:2014-08-15
  • 通讯作者: 王建军

Related Research of Endometrial Cancer and microRNA

LIU Qi-wei，YANG Min，TONG Xiao-wen，WANG Jian-jun   

  1. Medical College，Tongji University，Shanghai 200092，China（LIU Qi-wei，YANG Min）；Department of Obstetrics and Gynecology，Tongji Hospital，Shanghai 200065，China（TONG Xiao-wen，WANG Jian-jun）
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-08-15 Online:2014-08-15
  • Contact: WANG Jian-jun

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5180

被引次数

5

摘要： 微小RNA（microRNA，miRNA）是一种通过翻译后、转录和转录后水平调控mRNA的单链非编码RNA，可作为抑癌基因和癌基因参与肿瘤的发生、发展及侵袭。近期研究发现一些miRNA与子宫内膜癌（EC）的癌基因表达有关，例如miRNA-200家族，miRNA-205，miR-129-2，miR-203，miR-302，miR-194，miR-30c，miR-204，miR-34，miR-125，miRNA-152，miRNA-503等，均已证实与EC的癌基因具有相关性。随着对miRNAs研究的不断深入，miRNA有望成为EC的有效新靶点之一应用于临床。现综述近年与EC相关的miRNA研究进展。

关键词: 子宫内膜肿瘤, 癌, 微RNAs, 预测, 治疗

Abstract: microRNAs（miRNAs） are non-coding RNAs that can regulate mRNA in the level of post-translational modification，transcription and post-transcription. And they are associated with growth，development and invading of tumors as oncogenic miRNAs and tumor suppressor miRNAs. Relationships of miRNAs with endometrial cancer（EC） have recently emerged. For instance，miRNA-200 family，miRNA-205，miR-129-2，miR-203，miR-302，miR-194，miR-30c，miR-204，miR-34，miR-125，miRNA-152，miRNA-503，etc. With the deeper research，miRNAs may be used in clinical applications as one of new targets. In this article，there is an overview about the recent research of miRNAs and EC.

Key words: Endometrial neoplasms, Carcinoma, MicroRNAs, Forecasting, Therapy