国际妇产科学杂志

国际妇产科学杂志 ›› 2014, Vol. 41 ›› Issue (6): 613-616.

• 综述 • 上一篇    下一篇

人乳头瘤病毒与宫颈上皮内瘤样病变术后复发的关系

王雅卉，仝进毅   

  1. 310006 杭州市第一人民医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-12-15 发布日期:2014-12-15

The Relationship between Human Papillomavirus and Cervical Intraepithelial Neoplasia Recurrence

WANG Ya-hui，TONG Jin-yi   

  1. Department of Obstetrics and Gynecology，Hangzhou First People′s Hospital，Hangzhou 310006，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-12-15 Online:2014-12-15

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摘要： 宫颈上皮内瘤样病变（CIN）是一种癌前病变，可分为CINⅠ、CINⅡ和CINⅢ。国内对CINⅡ及以上者主要采取手术治疗，但术后仍有一定的复发率。影响复发的因素较多，包括切缘阳性、宫颈管诊刮阳性、机体免疫力降低、高龄等。人乳头瘤病毒（HPV）与CIN复发的关系尚不十分明确，但基本能够确定HPV持续感染可增加CIN复发率，且HPV亚型和HPV负荷量在其中起重要作用。综述HPV对CIN复发的影响。

关键词: 人乳头瘤病毒16, 宫颈上皮内瘤样病变, 基因型, 复发

Abstract: Cervical intraepithelial neoplasia （CIN） is a precancerous change，which can be divided into grade one，grade two and grade three. The disease should be taken to surgery when the pathologic change is more serious than CINⅠ. But there is still some postoperative recurrence rate. There are plenty of factors affecting the recurrence rate，including positive margins，positive endocervical curettage，reduced immunity，senium and so on. Until now，the relationship between HPV and the recurrence rate is not clear，but it′s confirmed that the persistent infection with HPV must increase the recurrence rate. Furthermore，the load of HPV and subtypes of HPV have played an important role in increasing the rate of CIN recurrence. This paper described the influence of HPV on CIN recurrence.

Key words: Human papillomavirus 16, Cervical intraepithelial neoplasia, Genotype, Recurrence