国际妇产科学杂志

国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (3): 245-248.

• 综述 •    下一篇

炎性体抗病毒信号通路与宫颈癌

罗远材，张玉华   

  1. 300192 天津市第一中心医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-06-15 发布日期:2015-06-15
  • 通讯作者: 张玉华

Inflammasome Antiviral Signaling Pathway and Cervical Cancer

LUO Yuan-cai，ZHANG Yu-hua   

  1. Department of Obstetrics and Gynecology，Tianjin First Central Hospital，Tianjin 300192，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-06-15 Online:2015-06-15
  • Contact: ZHANG Yu-hua

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5407

被引次数

2

摘要： 炎性体是存在于免疫活性细胞内的大分子、多蛋白复合体，能够感受细菌、病毒等外在病原体的刺激激活半胱氨酸天冬氨酸蛋白酶1（caspase-1），促进白细胞介素1β（IL-1β）和IL-18前体的加工成熟，参与机体炎性反应与免疫应答，诱导一种特殊的细胞死亡，即细胞焦亡（pyroptosis）。细胞焦亡是一种不同于凋亡和坏死的程序性细胞死亡形式，其特点为细胞在死亡过程中发生渗透性崩解，释放大量的炎性细胞因子，对邻近细胞产生促炎效应，快速启动天然免疫，能够对抗肿瘤的形成。综述近年炎性体抗病毒信号通路与宫颈癌相关的研究进展。

关键词: 多蛋白复合物, 宫颈肿瘤, 乳头状瘤病毒科, 半胱氨酸天冬氨酸蛋白酶1, 白细胞介素1β, 细胞焦亡

Abstract: The inflammasome is large molecule and multiprotein complex existing in immune active cells，which can feel external pathogens such as bacteria and viruses to activate cysteinyl aspartatespecific protease 1（caspase-1），and promote the precursors of interleukin 1 β（IL-1β） and IL-18 to process and mature，involve in the body′s inflammatory response and immune response，induce a special type of cell death called pyroptosis. Pyroptosis is a kind of programmed cell death which is different from apoptosis and necrosis，its characteristics is that osmotic collapse occurs during the process of cells death and releases large amounts of inflammatory cytokines，produces proinflammatory effects on adjacent cells，starts innate immune quickly and fights against tumor formation. The inflammasome antiviral signaling pathway research progress associated with cervical cancer in recent years are reviewed.

Key words: Multiprotein complexes, Uterine cervical neoplasms, Papillomaviridae, Caspase 1, Interleukin-1beta, Pyroptosis