国际妇产科学杂志

国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (3): 327-329.

• 综述 • 上一篇    下一篇

高迁移率族蛋白B1及其受体与早产关系的研究进展

邱晓媛，尹利荣   

  1. 300100 天津市中心妇产科医院（邱晓媛）；天津医科大学第二医院妇产科（尹利荣）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-06-15 发布日期:2015-06-15
  • 通讯作者: 尹利荣

Progress of High-mobility Group Box-1 and Its Receptors in Premature Birth

QIU Xiao-yuan，YIN Li-rong   

  1. Tianjin Central Hospital of Gynecology Obstetrics，Tianjin 300100，China（QIU Xiao-yuan）；Department of Obstetrics and Gynecology，The Second Hospital of Tianjin Medical University，Tianjin 300211，China（YIN Li-rong）
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-06-15 Online:2015-06-15
  • Contact: YIN Li-rong

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摘要： 感染是导致早产的主要环境因素之一。警报素（alarmin）概念的提出至今不足10年，但已逐渐显示出其在调节感染相关的免疫反应中所起的关键作用。高迁移率族蛋白B1（high-mobility group box-1，HMGB1）是一个多功能的警报素，参与了多种疾病的发生发展，包括感染性疾病。近年研究显示HMGB1可通过其受体Toll样受体4（toll-like receptor 4，TLR4）和晚期糖基化终产物受体（receptor for advanced glycation end products，RAGE）参与感染所致早产的发生和发展。根据该领域最新进展，依次综述了HMGB1、TLR4、RAGE以及后两者各自的可溶性形式在早产中的作用和意义，指出TLR4介导的急性炎症与RAGE介导的慢性炎症可能在早产的发生发展过程中共同发挥作用，HMGB1及其受体的可溶性形式有望成为简便、高效的早产相关的生物标记物。

关键词: HMGB1蛋白质, 早产, Toll样受体4, 晚期糖基化终产物受体, 炎症

Abstract: Infection has been associated with premature birth. Alarmin，a concept has just been coined for less than ten years, has emerged as a key mediator in the regulation of immune responses to infection. High-mobility group box protein 1（HMGB1） is a multifunctional alarmin involved in many human diseases including infectious diseases. Recent reports indicated that HMGB1 was involved in infection-induced premature birth through its receptors toll-like receptor 4（TLR4） and receptor for advanced glycation end products（RAGE）. In this review，we will discuss the role of HMGB1，as well as its receptors TLR4 and RAGE in premature birth. Acute inflammation induced by TLR4 and chronic inflammation mediated by RAGE may contribute to inflammation-induced premature birth. HMGB1 and its receptors could become important biomarkers of premature birth.

Key words: HMGB1 protein, Premature birth, Toll-like receptor 4, Receptor for advanced glycation end products, Inflammation