国际妇产科学杂志

国际妇产科学杂志 ›› 2017, Vol. 44 ›› Issue (2): 225-227.

• 论著 • 上一篇    下一篇

影响妊娠期急性脂肪肝预后的危险因素分析

潘华，张丽娟，夏爱斌   

  1. 410008  长沙，湖南省妇幼保健院产科（潘华）；中南大学湘雅二医院妇产科（张丽娟）；中南大学湘雅三医院妇产科（夏爱斌）
  • 收稿日期:2016-10-17 修回日期:2017-02-06 出版日期:2017-04-15 发布日期:2017-05-18
  • 通讯作者: 张丽娟，E-mail：zlj621116@sina.com E-mail:lijuanzhang11@126.com;zlj621116@sina.com

The Risk Factors on Prognosis in Acute Fatty Liver of Pregnancy

PAN Hua；ZHANG Li-juan；XIA Ai-bin   

  1. Department of Gynaecology and Obstetrics，Second Xiangya Hospital, Central South University，Changsha 410011，China（ZHANG Li-juan）；Department of Gynaecology and Obstetrics，Third Xiangya Hospital，Central South University，Changsha 410013，China（XIA Ai-bin）
  • Received:2016-10-17 Revised:2017-02-06 Published:2017-04-15 Online:2017-05-18
  • Contact: ZHANG Li-juan，E-mail：zlj621116@sina.com E-mail:lijuanzhang11@126.com;zlj621116@sina.com

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摘要： 【摘  要】  目的：探讨影响妊娠期急性脂肪肝（AFLP）患者预后的危险因素，为改善AFLP患者预后提供临床依据。方法：回顾性分析AFLP患者62例，以患者生存（45例）或死亡（17例）作为预后分类，对患者一般资料及各实验室指标进行单因素分析及多因素Logistic回归分析。结果：2组患者的红细胞计数（RBC）、红细胞比容（HCT）、白细胞计数（WBC）、血红蛋白（HGB）、血小板（PLT）、总蛋白（TP）、总胆红素（TBIL）、白蛋白（ALB）、直接胆红素（DBIL）、肌酐（Cr）、凝血酶原时间（PT）、纤维蛋白原（Fib）、活化的部分凝血酶时间（APTT）、发病到就诊时间≤7 d的例数、就诊到终止妊娠时间≤24 h的例数、发病到终止妊娠时间≤14 d的例数，差异有统计学意义（均P＜0.05）。就诊到终止妊娠超过24 h、发病到终止妊娠时间超过14 d是AFLP患者预后的危险因素。结论：就诊到终止妊娠时间和发病到终止妊娠时间是影响AFLP预后的重要因素。

关键词:    , 【关键词】 , 妊娠并发症, 脂肪肝, 产妇死亡率, Logistic模型, 妊娠期急性脂肪肝

Abstract: 【Abstract】  Objective：To investigate the factors influencing the prognosis of patients with acute fatty liver of pregnancy (AFLP), and to provide a clinical basis for improving the prognosis of AFLP patients. Methods：62 patients with AFLP were retrospectively analyzed. They were divided into 2 groups, Survival group and death group, according to the prognosis. Single factor and multivariate logistic regression were used to analyze the general data and the laboratory indexes of patients. Results：There were no significantly difference between survival group and death group on red blood cell count, hematocrit, hemoglobin, platelets, total protein, total bilirubin, alanine aminotransferase, aspartate aminotransferase, albumin, direct bilirubin, creatinine, PT, Fib, APTT in plasma, and the time from treatment to termination of pregnancy time and onset to termination of pregnancy (P＜0.05). Furthermore the time during treatment to termination of pregnancy over 24 h and the time during onset to termination of pregnancy over 14 d were the risk factor on prognosis of patients with AFLP. Conclusions：The time during treatment to termination of pregnancy and the time during onset to termination of pregnancy play a key role on prognosis in AFLP.

Key words: 【Keywords】 , Pregnancy complications, Fatty liver, Maternal mortality, Logistic models, Acute fatty liver of pregnancy