国际妇产科学杂志

国际妇产科学杂志 ›› 2018, Vol. 45 ›› Issue (1): 80-84.

• 综述 • 上一篇    下一篇

PPAR γ在子宫内膜癌中的研究进展

黄梅梅，毛晓丹，孙蓬明   

  1. 350001  福州，福建省妇幼保健院 福建医科大学附属医院
  • 收稿日期:2017-11-24 修回日期:2018-01-17 出版日期:2018-02-15 发布日期:2018-02-15
  • 通讯作者: 孙蓬明，E-mail：sunfemy@hotmail.com E-mail:446380361@qq.com
  • 基金资助:
    福建省自然科学基金（2016J01428，2017J01233）

Research Progress of PPAR γ in Endometrial Cancer

HUANG Mei-mei，MAO Xiao-dan，SUN Peng-ming   

  1. Fujian Provincial Maternity and Children Hospital，Affiliated Hospital of Fujian Medical University，Fuzhou 350001，China
  • Received:2017-11-24 Revised:2018-01-17 Published:2018-02-15 Online:2018-02-15
  • Contact: SUN Peng-ming, E-mail：sunfemy@hotmail.com E-mail:446380361@qq.com

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摘要： 过氧化氢酶增殖物激活受体（peroxisome proliferator-activated receptors，PPARｓ）是细胞核雌激素受体家族成员，包括PPAR α、β/δ和γ。PPAR γ参与脂肪与碳水化合物的代谢过程，因与多种代谢性疾病及肿瘤形成密切相关而成为研究的热点。PPAR γ是配体依赖的转录因子，与子宫内膜癌细胞的增殖、侵袭和转移有关，但在子宫内膜癌中的研究较少，且具体作用机制尚不明确。综述PPAR γ在子宫内膜癌相关的研究进展，旨在探讨PPAR γ参与子宫内膜癌发生发展的机制，为临床后续的抗肿瘤治疗提供理论依据。

关键词: PPAR γ, 子宫内膜肿瘤, 维甲类X受体, 信号传导, 过氧化氢酶增殖物激活受体-γ激动剂

Abstract: Peroxisome proliferator-activated receptors (PPARs) are members of nuclear-hormone-receptor family which including PPARα, β/δ and γ. As a hotspot of researches in recent years, PPAR γ is closely related to a variety of metabolic diseases and tumors, which plays an important role in metabolism of lipid and carbohydrate. It functions as ligand-dependent transcription factors, connected with the proliferation，invasion and migration of endometrial cancer cells. The role of PPAR γ in tumorigenesis of endometrial cancer remains unclear. In this article, we reviewed studies progress of PPAR γ in endometrial cancer, discussing the role of PPAR γ in tumorigenesis of endometrial cancer and potential mechanism underlying endometrial cancer development and furthering propose theoretical basis for anti-tumor therapy.

Key words: PPAR gamma, Endometrial neoplasms, Retinoid X receptors, Signal transduction, Peroxisome proliferator-activated &gamma, agonist