棕色脂肪组织及其与多囊卵巢综合征相关性研究新进展

国际妇产科学杂志 ›› 2018, Vol. 45 ›› Issue (2): 188-191.

棕色脂肪组织及其与多囊卵巢综合征相关性研究新进展

李子涵，李修阳，张宁，武志娟，周冠伦，李晓霞

250014 济南，山东中医药大学（李子涵，李修阳，张宁，周冠伦，李晓霞）；山东中医药大学附属医院（武志娟）

收稿日期:2018-01-18 修回日期:2018-02-14 出版日期:2018-04-15 发布日期:2018-04-15
通讯作者: 李修阳，E-mail：jack092284@163.com E-mail:ning_zhang1975@163.com
作者简介:2018-07-01
基金资助:
山东省自然科学基金（ZR2017BH062）；山东省重点研发计划项目（2017GSF19107）

New Research Progress on the Relationship between Brown Fat Tissue and Polycystic Ovary Syndrome

LI Zi-han，LI Xiu-yang，ZHANG Ning，WU Zhi-juan，ZHOU Guan-lun，LI Xiao-xia

Shandong University of Traditional Chinese Medicine，Ji'nan 250014，China（LI Zi-han，LI Xiu-yang，ZHANG Ning，ZHOU Guan-lun，LI Xiao-xia）；Affiliated Hospital of Shandong University of Traditional Chinese Medicine，Ji'nan 250014，China（WU Zhi-juan）

Received:2018-01-18 Revised:2018-02-14 Published:2018-04-15 Online:2018-04-15
Contact: LI Xiu-yang，E-mail：jack092284@163.com E-mail:ning_zhang1975@163.com

摘要/Abstract

摘要： 多囊卵巢综合征（polycystic ovarian syndrome，PCOS）是常见生殖代谢障碍性疾病，具有高度异质性，以肥胖、胰岛素抵抗（IR）、多毛、不孕为主要表现，后期引发心脑血管疾病、卵巢癌等远期并发症，对患者身心健康造成严重危害。棕色脂肪组织（brown adipose tissue，BAT）是人体产热的主要组织，在新陈代谢过程中发挥重要作用。研究发现，BAT与PCOS的形成关系密切，一方面BAT代谢障碍引发的肥胖进一步加速了IR、排卵异常及相关并发症的发生；另一方面，BAT特异性分泌的细胞因子是减轻IR，并降低PCOS炎症状态的关键。与此同时，针对BAT与PCOS的关系研究而衍生了包括外源性BAT移植、鸢尾素因子补充、药物诱导脂肪组织棕色化等治疗方法，使PCOS治疗手段多样化。现就BAT及其与PCOS关系的研究进展进行综述。

关键词: 脂肪组织, 棕色, 多囊卵巢综合征, 胰岛素抗药性, 肥胖症, 代谢综合征

Abstract: Polycystic ovarian syndrome (PCOS) is a common disorder of reproductive metabolism with high heterogeneity. Its main manifestations are obesity, insulin resistance (IR), hirsutism, infertility, late onset of cardiovascular and cerebrovascular diseases, ovarian cancer and other long-term complications. Brown adipose tissue (BAT) is the main body heat producing tissue and plays an important role in metabolism. It has been found that BAT is closely related to the formation of PCOS. On the one hand, obesity caused by metabolic disorders of BAT further accelerates the occurrence of abnormal ovulation and related complications; on the other hand, the cytokines secreted by BAT are the key to alleviate IR and reduce the inflammatory state of PCOS. Based on the study of the relationship between BAT and PCOS, we have derived the treatment methods including exogenous BAT transplantation, iris factor supplement, drug-induced adipose tissue browning and so on, so as to diversify the treatment methods of PCOS. In this paper, the research progress of BAT and its relationship with PCOS is reviewed.

Key words: Adipose tissue, brown, Polycystic ovary syndrome, Insulin resistance, Obesity, Metabolic syndrome

李子涵，李修阳，张宁，武志娟，周冠伦，李晓霞. 棕色脂肪组织及其与多囊卵巢综合征相关性研究新进展[J]. 国际妇产科学杂志, 2018, 45(2): 188-191.

LI Zi-han，LI Xiu-yang，ZHANG Ning，WU Zhi-juan，ZHOU Guan-lun，LI Xiao-xia. New Research Progress on the Relationship between Brown Fat Tissue and Polycystic Ovary Syndrome[J]. Journal of International Obstetrics and Gynecology, 2018, 45(2): 188-191.

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