关键词: 高血压, 妊娠性；, 胎盘；, 胚胎植入；, 胎盘功能不全；, 滋养层

Abstract: Hypertensive disorders of pregnancy (HDP) is an idiopathic disease of pregnancy, which seriously impact maternal and fetal health. It is a major cause of maternal and perinatal mortality, but its exact etiology and pathogenesis are still unclear. In recent years, it has been found that shallow implantation of placenta is an important mechanism of HDP. The factors influencing the process of shallow implantation of placenta can be divided into three aspects. The first is to affect the invasion ability of traphoblasts, mainly including hypoxia, cytokines, epigenetic regulation. The second is to influence the infiltration process of inflammatory factors, including chemokine family and decidual natural killer cells. The third is the degree of degradation of extracellular matrix, mainly including matrix metalloproteinases (MMPs) and related influencing factors. The mechanism of placental shallow implantation of HDP was reviewed in order to provide a new direction for early diagnosis, treatment and prevention of clinical diseases.

Key words: Hypertension, pregnancy-induced；, Placenta；Embryo implantation；, Placental insufficiency；, Trophoblasts