关键词: 先兆子痫；, 血管内皮损伤；, 内皮, 血管；, 微粒体；, 胎盘；, 胞外诱捕网

Abstract: Pre-eclampsia is one of the idiopathic diseases that cause maternal and perinatal deaths, and the specific pathogenesis is not elucidated. Current research suggests that pre-eclampsia is mainly related to the obstruction of uterine spiral arterioles due to abnormal invasion of placental trophoblasts, vascular endothelial cell damage, and excessive activation of inflammatory immune response. Recent studies have shown that microparticles can cause systemic inflammatory responses in patients with pre-eclampsia and participate in the pathogenesis of pre-eclampsia by regulating the release of neutrophil extracellular traps. At the same time, related studies have shown that neutrophil activation and adhesion to vascular endothelial cells stimulate inflammation, which is the key link of vascular endothelial injury in pre-eclampsia patients. When activated neutrophils form neutrophil extracellular traps that are excessive or not cleared by the body in time, neutrophil extracellular traps attach to the vascular endothelium, causing endothelial cells to undergo apoptosis, leading to vascular endothelial cells damage. This article reviews the research progress on the role of microparticles in regulating the release of neutrophil extracellular traps in the pathogenesis of pre-eclampsia.

Key words: Pre-eclampsia, Vascular endothelial injury, Endothelium, vascular, Microsomes, Placenta;, Extracellular traps