国际妇产科学杂志 ›› 2020, Vol. 47 ›› Issue (5): 495-497.

• 普通妇科疾病及相关研究 综述 • 上一篇    下一篇

富血小板血浆在宫腔粘连中的应用及现状

张盼盼,郝丽娟   

  1. 401120 重庆市妇幼保健院
  • 收稿日期:2020-03-05 修回日期:2020-03-10 出版日期:2020-10-15 发布日期:2020-10-27
  • 通讯作者: 郝丽娟,E-mail:haolj2002@163.com E-mail:haolj2002@163.com

Application and Status of Platelet-Rich Plasma in Intrauterine Adhesion

ZHANG Pan-pan,HAO Li-juan   

  1. Chongqing Health Center for Women and Children,Chongqing 401120,China
  • Received:2020-03-05 Revised:2020-03-10 Published:2020-10-15 Online:2020-10-27
  • Contact: HAO Li-juan,E-mail:haolj2002@163.com E-mail:haolj2002@163.com

摘要: 富血小板血浆是从自身血液中提取出来的一种生物制剂,血小板生物活性在炎症、细胞增殖和组织愈合中起重要作用。富血小板血浆产品已被用于促进皮肤、骨骼、肌肉损伤的愈合和调节炎症。宫腔粘连由于损伤内膜基底层,造成不孕及闭经等,对有生育要求妇女造成了很大困扰。宫腔粘连治疗需要手术分离粘连,预防术后复发,修复内膜,改善生育结局。富血小板血浆能够调节炎症和促进组织愈合,为宫腔粘连患者带来了新的希望。富血小板血浆来源于自体血,临床应用是安全的。综述富血小板血浆的概述、作用机制、临床应用及在宫腔粘连中的作用和现状。

关键词: 子宫疾病;, 组织黏连;, 富血小板血浆;, 妊娠;, 不育, 女(雌)性;, 子宫内膜增生

Abstract: Platelet-rich plasma (PRP) is a kind of biological agent derived from autogenous blood. Platelet bioactivity plays an important role in inflammation, cell proliferation and tissue healing. Therefore, PRP products have been used to promote the healing of skin, bone and muscle injury and regulate inflammation. Intrauterine adhesion, which damage the basal layer of endometrium, causes infertility and amenorrhea, etc., so causes a great deal of trouble for women with fertility requirement. The treatment of intrauterine adhesion requires surgical separation of adhesions, prevention of postoperative recurrence, repair of endometrium, and improvement of fertility outcome. PRP can regulate inflammation and promote tissue healing, which brings new hope to patients with intrauterine adhesion. Since PRP comes from autogenous blood, it is safe in clinical application. This paper reviews the overview, mechanism, clinical application of PRP and its role and status in intrauterine adhesion.

Key words: Uterine diseases;, Tissue adhesions;, Platelet-rich plasma;, Pregnancy;, Infertility, female;, Endometrial hyperplasia