MAPK信号通路在PCOS中的作用机制及中药单体的药理研究进展

doi:10.12280/gjfckx.20240713

摘要/Abstract

摘要：

多囊卵巢综合征（polycystic ovary syndrome，PCOS）是一种常见且复杂的妇科内分泌疾病，主要影响育龄期女性，其主要特征包括排卵障碍、胰岛素抵抗和高雄激素血症。丝裂原激活的蛋白激酶（mitogen-activated protein kinase，MAPK）信号通路在PCOS的发生中发挥着重要作用。已证实3条经典的MAPK通路——细胞外信号调节激酶（extracellular signal-regulated kinase，ERK）、c-Jun氨基端激酶（c-Jun N-terminal kinase，JNK）、p38 MAPK与PCOS的发病关系密切。一旦这些通路出现异常激活，将会促使机体出现多种不良反应，最终引发PCOS。具体包括排卵功能失调、胰岛素抵抗、雄激素水平升高、氧化应激以及炎症反应。研究表明，多种中药单体能够对MAPK信号通路相关蛋白的活性和表达进行调节。这些中药单体涵盖了黄酮类、苷类、萜类、生物碱类以及多糖类等，它们通过这种调节作用，有效改善PCOS患者的病理生理过程，从而为PCOS的治疗提供新的思路和方法。

关键词: 多囊卵巢综合征, 丝裂原激活蛋白激酶类, 中药单体, 胰岛素抵抗, 雄激素增多症

Abstract:

Polycystic ovary syndrome (PCOS) is a common and complex gynecological endocrine disorder that mainly affects women of childbearing age. Its main characteristics include ovulation disorders, insulin resistance and hyperandrogenemia. The mitogen-activated protein kinase (MAPK) signaling pathway plays an important role in the occurrence of PCOS. It has been confirmed that the three classic MAPK pathways - extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 MAPK are closely related to the occurrence of PCOS. Once these pathways are abnormally activated, it will prompt the body to have a variety of adverse reactions and ultimately lead to PCOS. Specifically, it includes ovulation dysfunction, insulin resistance, elevated androgen levels, oxidative stress and inflammatory reactions. Studies have shown that a variety of traditional Chinese medicine monomers can regulate the activity and expression of MAPK signaling pathway-related proteins. These traditional Chinese medicine monomers include flavonoids, glycosides, terpenoids, alkaloids and polysaccharides. Through this modulation, they can effectively improve the pathophysiological process of PCOS patients, thus providing new ideas and methods for the treatment of PCOS.

Key words: Polycystic ovary syndrome, Mitogen-activated protein kinases, Traditional Chinese medicine monomers, Insulin resistance, Hyperandrogenism

胡蝶, 任佳杰, 刘佳宁, 冯晓玲. MAPK信号通路在PCOS中的作用机制及中药单体的药理研究进展[J]. 国际妇产科学杂志, 2024, 51(6): 684-691.

HU Die, REN Jia-jie, LIU Jia-ning, FENG Xiao-ling. Mechanism Study of MAPK Pathway in PCOS and Monomeric Treatment of Traditional Chinese Medicine[J]. Journal of International Obstetrics and Gynecology, 2024, 51(6): 684-691.

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